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IPR028343 is a Fructose-1,6-bisphosphatase.
<p>Fructose bisphosphatase (FBPase) [ec:3.1.3.11] is a critical regulatory enzyme in gluconeogenesis that catalyses the removal of 1-phosphate from fructose 1,6-bis-phosphate to form fructose 6-phosphate [[cite:PUB00000153], [cite:PUB00000179]]. It is involved in many different metabolic pathways and found in most organisms. FBPase requires metal ions for catalysis (Mg<sup>2+</sup>and Mn<sup>2+</sup>being preferred) and the enzyme is potently inhibited by Li<sup>+</sup>. The fold of fructose-1,6-bisphosphatase was noted to be identical to that of inositol-1-phosphatase (IMPase) [[cite:PUB00000219]]. Inositol polyphosphate 1-phosphatase (IPPase), IMPase and FBPase share a sequence motif (Asp-Pro-Ile/Leu-Asp-Gly/Ser-Thr/Ser) which has been shown to bind metal ions and participate in catalysis. This motif is also found in the distantly-related fungal, bacterial and yeast IMPase homologues. It has been suggested that these proteins define an ancient structurally conserved family involved in diverse metabolic pathways, including inositol signalling, gluconeogenesis, sulphate assimilation and possibly quinone metabolism [[cite:PUB00004864]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Fructose 1,6-bisphosphate 1-phosphatase activity | Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: fructose-1,6-bisphosphatase, cytosolic-like [Cicer arietinum] gi|502180459|ref|XP_004516643.1| | 16 | ||
| – | PREDICTED: fructose-1,6-bisphosphatase, chloroplastic-like [Glycine max] gi|356568028|ref|XP_003552216.1| | 21 | ||
| – | PREDICTED: fructose-1,6-bisphosphatase, chloroplastic-like [Glycine max] gi|356521235|ref|XP_003529262.1| | 14 | ||
| – | Fructose-1,6-bisphosphatase [Pisum sativum] gi|5305145|emb|CAB46084.1| | 17 | ||
| – | PREDICTED: fructose-1,6-bisphosphatase, cytosolic-like [Glycine max] gi|356525912|ref|XP_003531565.1| | 14 | ||
| – | PREDICTED: fructose-1,6-bisphosphatase, cytosolic-like [Glycine max] gi|356525912|ref|XP_003531565.1| | 16 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT3G54050.1 high cyclic electron flow 1; Swiss-Prot: sp|P46275|F16P1_PEA Fructose-1,6-bisphosphatase, chloroplastic; TrEMBL-Plants: tr|I3T2L8|I3T2L8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0574000 | 21 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT1G43670.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P46276|F16P2_SOLTU Fructose-1,6-bisphosphatase, cytosolic; TrEMBL-Plants: tr|I3S7B9|I3S7B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0132900 | 16 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT1G43670.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P46276|F16P2_SOLTU Fructose-1,6-bisphosphatase, cytosolic; TrEMBL-Plants: tr|I3S7B9|I3S7B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0132900 | 16 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT1G43670.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P46276|F16P2_SOLTU Fructose-1,6-bisphosphatase, cytosolic; TrEMBL-Plants: tr|I3S7B9|I3S7B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0132900 | 17 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT1G43670.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P46276|F16P2_SOLTU Fructose-1,6-bisphosphatase, cytosolic; TrEMBL-Plants: tr|I3S7B9|I3S7B9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0132900 | 16 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT5G64380.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P22418|F16P1_SPIOL Fructose-1,6-bisphosphatase, chloroplastic; TrEMBL-Plants: tr|I3T6G2|I3T6G2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0039900 | 14 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT5G64380.1 Inositol monophosphatase family protein; Swiss-Prot: sp|Q07204|F16P1_BRANA Fructose-1,6-bisphosphatase, chloroplastic; TrEMBL-Plants: tr|I3T6G2|I3T6G2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0039900 | 13 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT1G43670.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P46276|F16P2_SOLTU Fructose-1,6-bisphosphatase, cytosolic; TrEMBL-Plants: tr|A0A059BU66|A0A059BU66_EUCGR Uncharacterized protein; Found in the gene: LotjaGi5g1v0291200 | 16 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT1G43670.1 Inositol monophosphatase family protein; Swiss-Prot: sp|P46276|F16P2_SOLTU Fructose-1,6-bisphosphatase, cytosolic; TrEMBL-Plants: tr|A0A0B2QB13|A0A0B2QB13_GLYSO Fructose-1,6-bisphosphatase, cytosolic; Found in the gene: LotjaGi5g1v0291200 | 16 | ||
| – | Fructose-1,6-bisphosphatase class 1; TAIR: AT1G43670.1 Inositol monophosphatase family protein; Swiss-Prot: sp|A2WXB2|F16P2_ORYSI Fructose-1,6-bisphosphatase, cytosolic; TrEMBL-Plants: tr|I1KUG8|I1KUG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0356500 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00354 | CDD | 1 | 6.25 |