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IPR028614 is a GDP-L-fucose synthase/GDP-L-colitose synthase.
<p>GDP-L-fucose synthase is responsible for the last step of the major metabolic pathway resulting in GDP-L-fucose synthesis from GDP-D-mannose. It catalyses a combined epimerase and NADPH-dependent reductase reaction, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose [[cite:PUB00068854]]. Since several cell-surface antigens, including the leukocyte Lewis system and cell-surface antigens in pathogenic bacteria, depend on the availability of GDP-L-fucose for their expression, the enzyme is a potential target for therapy in pathological states depending on selectin-mediated cell-to-cell interactions [[cite:PUB00024463]].</p> <p>This entry also includes ColC from Yersinia pseudotuberculosis. ColC is a GDP-L-colitose synthase, which is a bifunctional enzyme catalysaing the C-5 epimerization of GDP-4-keto-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose [[cite:PUB00078586]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Nucleotide-sugar biosynthetic process | The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. | ||
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | GDP-L-fucose synthase [Medicago truncatula] gi|357511215|ref|XP_003625896.1| | 11 | ||
| – | UDP-glucose 4-epimerase 3; TAIR: AT1G17890.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9LMU0|FCL2_ARATH Putative GDP-L-fucose synthase 2; TrEMBL-Plants: tr|I1L759|I1L759_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0449500 | 11 | ||
| – | GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; TAIR: AT1G17890.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q9LMU0|FCL2_ARATH Putative GDP-L-fucose synthase 2; TrEMBL-Plants: tr|I1L759|I1L759_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0051000 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05239 | CDD | 1 | 33.33 |