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IPR029003

Source: InterPro

Description

IPR029003 is a CENP-S/Mhf1.

<p>This entry includes animal centromere protein S (CENP-S) and its yeast homologue, Mhf1. CENP-S/Mhf1 is a component of the FANCM-MHF complex, an essential DNA-remodeling complex that protects replication forks in response to DNA damage [[cite:PUB00054178], [cite:PUB00070223]]. FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork [[cite:PUB00054178]].</p> <p>CENP-S is a dual function protein. It aids DNA repair/recombination and localises to centromeres to promote chromosome segregation [[cite:PUB00070223]]. It is a kinetochore component that forms complexes with CENP-X to form a stable CENP-T-W-S-X heterotetramer [[cite:PUB00067486], [cite:PUB00058268], [cite:PUB00067771]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0071821
Cellular component FANCM-MHF complex A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj1g3v1441390.1
– Centromere protein S [Medicago truncatula] gi|357464945|ref|XP_003602754.1|
Domains
8
Lj1g3v1441390.2
– Centromere protein S [Medicago truncatula] gi|357464945|ref|XP_003602754.1|
Domains
8
LotjaGi1g1v0333200.1
– Centromere protein S; TAIR: AT5G50930.1 Histone superfamily protein; Swiss-Prot: sp|Q8N2Z9|CENPS_HUMAN Centromere protein S; TrEMBL-Plants: tr|G7J3A4|G7J3A4_MEDTR Transcription initiation factor IID, 31 kDa subunit; Found in the gene: LotjaGi1g1v0333200
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33