Description

IPR030389 is a FeoB-type guanine nucleotide-binding (G) domain.

<p>The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.</p> <p>The FeoB family of GTPases is widespread, although not ubiquitous, in Bacteria and Archaea, but missing from Eukaryota. FeoB is involved in the uptake of ferrous iron (Fe(2+)), an important cofactor in biological electron transfer and catalysis. Most of the FeoB proteins contain an N-terminal G-domain, connected by an entirely α-helical linker peptide to the membrane domain with 8 to 12 predicted membrane-spanning α-helices, while in some organisms the G-domain is expressed separately as a soluble protein. The FeoB- type G domain belongs to the TrmE-Era-EngA-EngB-Septin-like (TEES) superfamily of the TRAFAC class GTPases.</p> <p>The structure of the FeoB-type G domain follows the typical fold of small GTP- binding proteins, consisting of a seven-stranded β-sheet surrounded by five α-helices. The ~170-residue FeoB-type G domain harbours five short amino-acid motifs (G1-G5) that are critical in the binding of both a magnesium (Mg(2+)) ion and the guanine nucleotide. The G1 motif (GxxxxGKS/T) (P-loop) is in position to stabilise the beta- and gamma-phosphates of GTP by hydrogen bonds donated by main-chain amides. The threonine of the G2 motif (P/AGxT) coordinates the Mg(2+). The G3 motif (DxxG) interacts with the Mg(2+) and an oxygen of the gamma-phosphate. The G4 motif (NxxD) is involved in recognition of the guanine nucleotide by forming hydrogen bonds to the guanine base. The G5 motif (S/VSTV]) is, despite low sequence conservation, attributed to critical guanine base coordination [[cite:PUB00013952], [cite:PUB00052758], [cite:PUB00053086], [cite:PUB00058539], [cite:PUB00054426], [cite:PUB00054907]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 3

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: