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IPR030661 is a SUMO-activating enzyme subunit Uba2.
<p>The SUMO activating enzyme E1 enzyme facilitates conjugation of ubiquitin and ubiquitin-like proteins through adenylation, thioester transfer within E1, and thioester transfer from E1 to E2 conjugating proteins [[cite:PUB00038452]]. This entry represents a subunit of the E1 enzyme, including Uba2 from yeasts [[cite:PUB00002915]] and its homologue, SAE2 from animals [[cite:PUB00073560]]. E1 enzymes mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 [[cite:PUB00058677], [cite:PUB00048807]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein sumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. | ||
| Molecular function | SUMO activating enzyme activity | Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ubiquitin activating enzyme E1; TAIR: AT2G21470.1 SUMO-activating enzyme 2; Swiss-Prot: sp|Q9SJT1|SAE2_ARATH SUMO-activating enzyme subunit 2; TrEMBL-Plants: tr|V7ALR1|V7ALR1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0275000_LC | 8 | ||
| – | SUMO-activating enzyme 2; TAIR: AT2G21470.1 SUMO-activating enzyme 2; Swiss-Prot: sp|Q9SJT1|SAE2_ARATH SUMO-activating enzyme subunit 2; TrEMBL-Plants: tr|I1LVC3|I1LVC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0061900 | 17 | ||
| – | SUMO-activating enzyme 2; TAIR: AT2G21470.1 SUMO-activating enzyme 2; Swiss-Prot: sp|Q9SJT1|SAE2_ARATH SUMO-activating enzyme subunit 2; TrEMBL-Plants: tr|I1LVC3|I1LVC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0061900 | 16 | ||
| – | Adenylyltransferase and sulfurtransferase; TAIR: AT2G21470.1 SUMO-activating enzyme 2; Swiss-Prot: sp|Q9SJT1|SAE2_ARATH SUMO-activating enzyme subunit 2; TrEMBL-Plants: tr|V7ALR1|V7ALR1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0323700_LC | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF69572 | SUPERFAMILY | 1 | 25.00 |