Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR023318

Source: InterPro

Description

IPR023318 is a Ubiquitin activating enzyme, alpha domain superfamily.

<p>Ubiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on one of the many forms of ubiquitin-conjugating enzymes (E2) [[cite:PUB00044523]]. This domain carries the last of five conserved cysteines that is part of the active site of the enzyme, responsible for ubiquitin thiolester complex formation, the active site being represented by the sequence motif PICTLKNFP [[cite:PUB00044524]]. Not all proteins in this entry contain a functional active site.</p> <p>This superfamily represents an α orthogonal bundle domain found in ubiquitin-activating enzyme and ubiquitin-like NEDD8-activating enzyme.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj4g3v2400830.1
– PREDICTED: NEDD8-activating enzyme E1 catalytic subunit-like [Cicer arietinum] gi|502149911|ref|XP_004507708.1|
Domains
15
LotjaGi3g1v0061900.1
– SUMO-activating enzyme 2; TAIR: AT2G21470.1 SUMO-activating enzyme 2; Swiss-Prot: sp|Q9SJT1|SAE2_ARATH SUMO-activating enzyme subunit 2; TrEMBL-Plants: tr|I1LVC3|I1LVC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0061900
Domains
17
LotjaGi3g1v0061900.2
– SUMO-activating enzyme 2; TAIR: AT2G21470.1 SUMO-activating enzyme 2; Swiss-Prot: sp|Q9SJT1|SAE2_ARATH SUMO-activating enzyme subunit 2; TrEMBL-Plants: tr|I1LVC3|I1LVC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0061900
Domains
16
LotjaGi4g1v0352900.1
– NEDD8-activating enzyme E1 catalytic subunit; TAIR: AT5G19180.1 E1 C-terminal related 1; Swiss-Prot: sp|O65041|UBA3_ARATH NEDD8-activating enzyme E1 catalytic subunit; TrEMBL-Plants: tr|I1KNA2|I1KNA2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0352900
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01488 CDD 1 25.00