Description

IPR030700 is a N-end rule aminoacyl transferase.

<p>This entry represents a family of aminoacyl-transferases that includes prokaryotic aspartate/glutamate leucyltransferase, and eukaryotic arginine-tRNA-protein transferase.</p> <p>Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis [[cite:PUB00009970]]. In Saccharomyces cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity [[cite:PUB00009971]]. Of these, only Cys 94 appears to be completely conserved in this family.</p> <p>Aspartate/glutamate leucyltransferase (also known as bacterial protein transferase or Bpt) functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. This protein shows sequence similarity to the eukaryotic N-end rule pathway component arginyl-transferase Ate1 [[cite:PUB00088202]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: