Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR007472 is a N-end rule aminoacyl transferase, C-terminal.
<p>This entry represents the C-terminal region of aminoacyl-transferases found in both eukaryotic (Arginine-tRNA-protein transferase) and prokaryotic (Aspartate/glutamate leucyltransferase) enzymes.</p> <p>Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis [[cite:PUB00009970]]. In Saccharomyces cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity [[cite:PUB00009971]]. Of these, only Cys 94 appears to be completely conserved in this family.</p> <p>Aspartate/glutamate leucyltransferase (also known as bacterial protein transferase or Bpt) functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. This protein shows sequence similarity to the eukaryotic N-end rule pathway component arginyl-transferase Ate1 [[cite:PUB00088202]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Arginyltransferase activity | Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein. | ||
| Biological process | Protein arginylation | The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Arginyl-tRNA--protein transferase; TAIR: AT5G05700.1 arginine-tRNA protein transferase 1; Swiss-Prot: sp|Q9ZT48|ATE1_ARATH Arginyl-tRNA--protein transferase 1; TrEMBL-Plants: tr|I1MZ35|I1MZ35_SOYBN Arginyl-tRNA--protein transferase; Found in the gene: LotjaGi6g1v0072400 | 12 | ||
| – | Arginyl-tRNA--protein transferase; TAIR: AT5G05700.1 arginine-tRNA protein transferase 1; Swiss-Prot: sp|Q9ZT48|ATE1_ARATH Arginyl-tRNA--protein transferase 1; TrEMBL-Plants: tr|I1MZ35|I1MZ35_SOYBN Arginyl-tRNA--protein transferase; Found in the gene: LotjaGi6g1v0072400 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |