Description

IPR016181 is a Acyl-CoA N-acyltransferase.

<p>This entry represents a structural domain found in several acyl-CoA acyltransferase enzymes. This domain has a 3-layer α/β/α structure that contains mixed β-sheets, and can be found in the following proteins:</p> <ul> <li>N-acetyl transferase (NAT) family members, including aminoglycoside N-acetyltransferases [[cite:PUB00027579]], the histone acetyltransferase domain of P300/CBP associating factor PCAF [[cite:PUB00023984]], the catalytic domain of GCN5 histone acetyltransferase [[cite:PUB00006453]], and diamine acetyltransferase 1 [[cite:PUB00039506]].</li> <li>Autoinducer synthetases, such as protein LasI [[cite:PUB00030742]] and acyl-homoserinelactone synthase EsaI [[cite:PUB00026875]].</li> <li>Leucyl/phenylalanyl-tRNA-protein transferase (LFTR), a close relative of the non-ribosomal peptidyltransferases; there is a deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events [[cite:PUB00040115]].</li> <li>Ornithine decarboxylase antizyme, which may have evolved a different function for this domain, although the putative active site maps to the same location in the common fold.</li> <li>Arginine N-succinyltransferase, alpha chain, AstA, which contains an extra C-terminal domain that is similar to the double-psi β-barrel fold domain (missing one strand and untangled ψ-loops).</li> </ul> <p>Several proteins carry a duplication of this domain, which consists of two NAT-like domains swapped with the C-terminal strands, including:</p> <ul> <li>N-myristoyl transferase (NMT) [[cite:PUB00026039]].</li> <li>FemXAB non ribosomal peptidyl transferases, including methicillin-resistance protein FemA (transfer glycyl residue from tRNA-Gly) [[cite:PUB00014008]] and peptidyl transferase FemX [[cite:PUB00029031]].</li> <li>Hypothetical protein cg14615-pa from Drosophila melanogaster (Fruit fly).</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 151