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IPR032157

Source: InterPro

Description

IPR032157 is a Proteasome assembly chaperone 4.

<p>The 26S proteasome plays a critical role in a number of cellular processes including cell-cycle control, transcription, signal transduction and DNA repair [[cite:PUB00016866]]. This complex is composed of a catalytic 20S proteasome and two axially positioned 19S regulatory complexes. The overall structure is highly conserved among eukaryotes and is essential for cell viability. Assembly of the catalytic 20S proteasome CP (core particle) initiates with the formation of rings composed of seven alpha subunits and involves proteasome-assembly chaperones PAC1-PAC2, PAC3-PAC4 and UMP1 [[cite:PUB00076216]]. Two heterodimeric proteasome-assembly chaperones, PAC1-PAC2 and PAC3-PAC4, interact with alpha subunits and promote the correct assembly of alpha rings. PAC3-PAC4 leaves the complex during subsequent assembly of beta subunits, while PAC1-PAC2 remains bound until the assembly of the CP is completed [[cite:PUB00076217]].</p> <p>This family consists of proteasome assembly chaperone 4 (PAC4, PSMG4). At the very C terminus there is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore [[cite:PUB00076215]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0043248
Biological process Proteasome assembly The aggregation, arrangement and bonding together of a mature, active proteasome complex.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj6g3v1126340.1
– PREDICTED: proteasome assembly chaperone 4-like [Fragaria vesca subsp]. vesca] gi|470122119|ref|XP_004297097.1|
Domains
4
LotjaGi6g1v0216900.1
– Proteasome assembly chaperone 4; TAIR: AT1G48170.1 proteasome assembly chaperone; Swiss-Prot: sp|Q5JS54|PSMG4_HUMAN Proteasome assembly chaperone 4; TrEMBL-Plants: tr|I3S521|I3S521_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0216900
Domains
4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
PTHR33559 PANTHER 1 50.00