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IPR032696 is a Squalene cyclase, C-terminal.
<p>This entry represents the C-terminal domain of squalene cyclases [[cite:PUB00023140], [cite:PUB00022306], [cite:PUB00076752]].</p> <p>Several enzymes catalyse mechanistically related reactions which involve the highly complex cyclic rearrangement of squalene or its 2,3 oxide. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyse a cationic cyclisation cascade converting linear triterpenes to fused ring compounds [[cite:PUB00080775], [cite:PUB00005227]]. Lanosterol synthase ([ec:5.4.99.7]) (oxidosqualene-lanosterol cyclase) catalyses the cyclisation of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi (gene ERG7). Cycloartenol synthase ([ec:5.4.99.8]) (2,3-epoxysqualene-cycloartenol cyclase), is a plant enzyme that catalyses the cyclization of (S)-2,3-epoxysqualene to cycloartenol [[cite:PUB00080774]], and hopene synthase ([ec:5.4.99]) (squalene-hopene cyclase), is a bacterial enzyme that catalyses the cyclisation of squalene into hopene or diplopterol, a key step in hopanoid (triterpenoid) metabolism [[cite:PUB00023140], [cite:PUB00080784]] also found in Aspergillus fumigatus as part of the gene cluster that mediates the biosynthesis fumihopaside A [[cite:PUB00097904]]. These enzymes are evolutionary related [[cite:PUB00004809]] proteins of about 70 to 85kDa and have an alpha 6 - alpha 6 barrel fold. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY [[cite:PUB00080779]]. Both enzymes have a second minor domain, which forms an α-α barrel that is inserted into the major domain.</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Oxidosqualene cyclase [Lotus japonicus] gi|108743267|dbj|BAE95409.1| | 10 | ||
– | Beta-amyrin synthase [Glycyrrhiza uralensis] gi|294488497|gb|ADE88148.1| | 7 | ||
– | Lanosterol synthase [Lotus japonicus] gi|108743269|dbj|BAE95410.1| | 16 | ||
– | Cycloartenol synthase [Lotus japonicus] gi|83016479|dbj|BAE53431.1| | 15 | ||
– | Cycloartenol synthase [Lotus japonicus] gi|83016479|dbj|BAE53431.1| | 7 | ||
– | Lupeol synthase [Lotus japonicus] gi|83016477|dbj|BAE53430.1| | 12 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 12 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 12 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 12 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 12 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 12 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 12 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 7 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 6 | ||
– | Beta-amyrin synthase [Lotus japonicus] gi|83016474|dbj|BAE53429.1| | 15 | ||
– | Beta-amyrin synthase [Lotus japonicus] gi|83016474|dbj|BAE53429.1| | 15 | ||
– | Beta-amyrin synthase [Lotus japonicus] gi|83016474|dbj|BAE53429.1| | 15 | ||
– | Beta-amyrin synthase [Lotus japonicus] gi|83016474|dbj|BAE53429.1| | 8 | ||
– | Beta-amyrin synthase [Glycyrrhiza uralensis] gi|294488497|gb|ADE88148.1| | 10 | ||
– | Multifunctional beta-amyrin synthase [Lotus japonicus] gi|28194508|gb|AAO33580.1|AF478455_1 | 7 | ||
– | Lanosterol synthase [Lotus japonicus] gi|108743269|dbj|BAE95410.1| | 13 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|E2IUB0|CASS_KALDA Cycloartenol synthase; TrEMBL-Plants: tr|Q1ERD3|Q1ERD3_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235000 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|P38605|CAS1_ARATH Cycloartenol synthase; TrEMBL-Plants: tr|Q1ERD4|Q1ERD4_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235100 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q9SXV6|CAS1_GLYGL Cycloartenol synthase; TrEMBL-Plants: tr|Q2WGL6|Q2WGL6_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235200 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q9SXV6|CAS1_GLYGL Cycloartenol synthase; TrEMBL-Plants: tr|Q2WGL6|Q2WGL6_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235200 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q9SXV6|CAS1_GLYGL Cycloartenol synthase; TrEMBL-Plants: tr|Q2WGL6|Q2WGL6_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235200 | 21 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q764T8|LUPS_GLYGL Lupeol synthase; TrEMBL-Plants: tr|Q2WGL7|Q2WGL7_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235400 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q764T8|LUPS_GLYGL Lupeol synthase; TrEMBL-Plants: tr|Q2WGL7|Q2WGL7_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235400 | 14 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q764T8|LUPS_GLYGL Lupeol synthase; TrEMBL-Plants: tr|Q2WGL7|Q2WGL7_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235400 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q764T8|LUPS_GLYGL Lupeol synthase; TrEMBL-Plants: tr|Q2WGL7|Q2WGL7_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235400 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT2G07050.1 cycloartenol synthase 1; Swiss-Prot: sp|Q764T8|LUPS_GLYGL Lupeol synthase; TrEMBL-Plants: tr|Q2WGL7|Q2WGL7_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi2g1v0235400 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78950.1 Terpenoid cyclases family protein; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|Q84PE1|Q84PE1_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0338300 | 12 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78955.1 camelliol C synthase 1; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|Q84PE1|Q84PE1_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0339100 | 12 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78955.1 camelliol C synthase 1; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|Q84PE1|Q84PE1_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0339100 | 12 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78950.1 Terpenoid cyclases family protein; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|Q2WGL8|Q2WGL8_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0340000 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78955.1 camelliol C synthase 1; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|Q2WGL8|Q2WGL8_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0340000 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78950.2 Terpenoid cyclases family protein; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|Q2WGL8|Q2WGL8_LOTJA Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0340000 | 15 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78950.2 Terpenoid cyclases family protein; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|A0A1D8GS88|A0A1D8GS88_9FABA Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0537500 | 13 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78955.1 camelliol C synthase 1; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|D7P7W7|D7P7W7_GLYUR Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0537800 | 10 | ||
– | Terpene cyclase/mutase family member; TAIR: AT1G78955.1 camelliol C synthase 1; Swiss-Prot: sp|Q9MB42|BAMS_GLYGL Beta-amyrin synthase; TrEMBL-Plants: tr|D7P7W7|D7P7W7_GLYUR Terpene cyclase/mutase family member; Found in the gene: LotjaGi3g1v0537800 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
TMhelix | TMHMM | 1 | 2.50 |