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IPR033658 is a Glutaredoxin, PICOT-like.
<p>This entry represents a glutaredoxin (GRX) domain found in PICOT (also known as glutaredoxin-3 or PKC-interacting cousin of thioredoxin) and GRX-PICOT-like proteins. The non-PICOT members of this group contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain followed by one to three GRX-like domains. It is interesting to note that PICOT from plants contain three repeats of the GRX-like domain, metazoan proteins (except for insect) have two repeats, while fungal sequences contain only one copy of the domain. PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT inhibits the activation of c-Jun N-terminal kinase and the transcription factors, AP-1 and NF-kB, induced by PKC theta or T-cell activating stimuli. Both GRX and TRX domains of PICOT are required for its activity [[cite:PUB00033585], [cite:PUB00016736], [cite:PUB00014033]]. Characterized non-PICOT proteins with this domain include CXIP1, a CAX-interacting protein in Arabidopsis thaliana, and PfGLP-1, a GRX-like protein from Plasmodium falciparum [[cite:PUB00079805], [cite:PUB00079804]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: monothiol glutaredoxin-S16, chloroplastic-like [Cicer arietinum] gi|502147321|ref|XP_004506738.1| | 14 | ||
| – | Glutaredoxin-like protein [Medicago truncatula] gi|357507677|ref|XP_003624127.1| | 12 | ||
| – | PREDICTED: monothiol glutaredoxin-S15, mitochondrial-like [Cicer arietinum] gi|502080829|ref|XP_004486694.1| | 18 | ||
| – | PREDICTED: monothiol glutaredoxin-S15, mitochondrial-like [Cicer arietinum] gi|502080829|ref|XP_004486694.1| | 12 | ||
| – | Monothiol glutaredoxin-S17 [Medicago truncatula] gi|358346673|ref|XP_003637390.1| | 13 | ||
| – | PREDICTED: monothiol glutaredoxin-S17-like [Glycine max] gi|356548735|ref|XP_003542755.1| | 16 | ||
| – | Glutaredoxin; TAIR: AT3G54900.1 CAX interacting protein 1; Swiss-Prot: sp|Q84Y95|GRS14_ARATH Monothiol glutaredoxin-S14, chloroplastic; TrEMBL-Plants: tr|I3T3L6|I3T3L6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0483500 | 12 | ||
| – | Glutaredoxin; TAIR: AT3G15660.1 glutaredoxin 4; Swiss-Prot: sp|Q8LBK6|GRS15_ARATH Monothiol glutaredoxin-S15, mitochondrial; TrEMBL-Plants: tr|I3T581|I3T581_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0012000 | 18 | ||
| – | Glutaredoxin; TAIR: AT2G38270.1 CAX-interacting protein 2; Swiss-Prot: sp|Q8H7F6|GRS16_ARATH Bifunctional monothiol glutaredoxin-S16, chloroplastic; TrEMBL-Plants: tr|V7AMR5|V7AMR5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0194300 | 16 | ||
| – | Glutaredoxin; TAIR: AT3G15660.1 glutaredoxin 4; Swiss-Prot: sp|Q8LBK6|GRS15_ARATH Monothiol glutaredoxin-S15, mitochondrial; TrEMBL-Plants: tr|I3S4N0|I3S4N0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0359300 | 12 | ||
| – | Glutaredoxin; TAIR: AT3G15660.1 glutaredoxin 4; Swiss-Prot: sp|Q8LBK6|GRS15_ARATH Monothiol glutaredoxin-S15, mitochondrial; TrEMBL-Plants: tr|I3S4N0|I3S4N0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0359300 | 12 | ||
| – | Monothiol glutaredoxin-related; TAIR: AT4G04950.1 thioredoxin family protein; Swiss-Prot: sp|Q9ZPH2|GRS17_ARATH Monothiol glutaredoxin-S17; TrEMBL-Plants: tr|G7ZZ90|G7ZZ90_MEDTR Monothiol glutaredoxin-S17 protein; Found in the gene: LotjaGi4g1v0055300 | 16 | ||
| – | Monothiol glutaredoxin-related; TAIR: AT4G04950.1 thioredoxin family protein; Swiss-Prot: sp|Q9ZPH2|GRS17_ARATH Monothiol glutaredoxin-S17; TrEMBL-Plants: tr|G7ZZ90|G7ZZ90_MEDTR Monothiol glutaredoxin-S17 protein; Found in the gene: LotjaGi4g1v0055300 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03028 | CDD | 1 | 7.69 |