Description

IPR035901 is a GIY-YIG endonuclease superfamily.

<p>Nucleases of the GIY-YIG family are involved in many cellular processes, including DNA repair and recombination, transfer of mobile genetic elements, and restriction of incoming foreign DNA. The GIY-YIG superfamily groups together nucleases characterised by the presence of a domain of typically ~100 amino acids, with two short motifs "GIY" and "YIG" in the N-terminal part, followed by an Arg residue in the centre and a Glu residue in the C-terminal part [[cite:PUB00019614], [cite:PUB00017038], [cite:PUB00032630], [cite:PUB00044989], [cite:PUB00063738]].</p> <p>The GIY-YIG domain forms a compact structural domain, which serves as a scaffold for the coordination of a divalent metal ion required for catalysis of the phosphodiester bond cleavage. The GIY-YIG domain has an α/β-sandwich architecture with a central three-stranded antiparallel β-sheet flanked by three-helices. The three-stranded antiparallel β-sheet contains the GIY-YIG sequence elements. The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site [[cite:PUB00017038], [cite:PUB00032630], [cite:PUB00044989], [cite:PUB00063738]].</p> <p>The GIY-YIG domain has been implicated in a variety of cellular processes involving DNA cleavage, from self-propagation with or without introns, to restriction of foreign DNA, to DNA repair and maintenance of genome stability [[cite:PUB00044989]].</p> <p>Some proteins known to contain a GIY-YIG domain include:</p> <ul> <li>Eukaryotic Slx-1 proteins, involved in the maintenance of the rDNA copy number. They have a C-terminal RING finger Zn-binding domain.</li> <li>Mammalian ankyrin repeat and LEM domain- containing protein 1 (ANKLE1).</li> <li>Bacterial and archaeal UvrC subunits of (A)BC excinucleases, which remove damaged nucleotides by incising the damaged strand on both sides of the lesion.</li> <li>Phage T4 endonucleases SegA to E, probably involved in the movement of the endonuclease-encoding DNA.</li> <li>Phage T4 intron-associated endonuclease 1 (I-TevI), specific to the thymidylate synthase (td) gene splice junction and involved in intron homing.</li> </ul> <p>This entry represents GIY-YIG nuclease superfamily, and identifies the GIY-YIG domain in diverse and distantly related superfamily members, such as Slx1 [[cite:PUB00044989]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: