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IPR033745 is a Mitochondria fission protein Fis1, cytosolic domain.
<p>Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane. Dnm1 is recruited to mitochondria via interactions with the adaptor proteins Caf4 and Mdv1, which bind directly to Fis1 [[cite:PUB00080501], [cite:PUB00080503]].</p> <p>The Fis1 N terminus is cytosolic and tethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. The cytosolic domain of Fis1 forms a six-helix bundle, in which the central four helices consist of two tandem tetratricopeptide repeat (TPR)-like motifs, known to mediate protein-protein interactions [[cite:PUB00048758], [cite:PUB00038450], [cite:PUB00022424], [cite:PUB00029287]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Mitochondrial fission 1 protein [Medicago truncatula] gi|357509485|ref|XP_003625031.1| | 17 | ||
| – | PREDICTED: mitochondria fission 1 protein-like isoform X2 [Cicer arietinum] gi|502098541|ref|XP_004491260.1| | 17 | ||
| – | Fission 1 protein; TAIR: AT3G57090.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M1J1|FIS1A_ARATH Mitochondrial fission 1 protein A; TrEMBL-Plants: tr|I3SYU6|I3SYU6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0048600 | 17 | ||
| – | Fission 1 protein; TAIR: AT3G57090.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M1J1|FIS1A_ARATH Mitochondrial fission 1 protein A; TrEMBL-Plants: tr|I3SYU6|I3SYU6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0048600 | 12 | ||
| – | Fission 1 protein; TAIR: AT3G57090.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M1J1|FIS1A_ARATH Mitochondrial fission 1 protein A; TrEMBL-Plants: tr|I3SLN5|I3SLN5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0665800 | 17 | ||
| – | Fission 1 protein; TAIR: AT3G57090.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M1J1|FIS1A_ARATH Mitochondrial fission 1 protein A; TrEMBL-Plants: tr|I3SLN5|I3SLN5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0665800 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd12212 | CDD | 1 | 16.67 |