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IPR033869 is a Phytepsin.
<p>This entry represents a domain found in phytepsin, along with some other aspartic proteases.</p> <p>Phytepsin (MEROPS identifier A01.020), is a plant homologue of mammalian lysosomal pepsins, which resides in grains, roots, stems, leaves and flowers. Phytepsin may participate in metabolic turnover and in protein processing events. In addition, it highly expressed in several plant tissues undergoing apoptosis. Phytepsin contains an internal region consisting of about 100 residues not present in animal or microbial pepsins. This region is thus called a plant specific insert. The insert is highly similar to saponins, which are lysosomal sphingolipid-activating proteins in mammalian cells. The saponin-like domain may have a role in the vacuolar targeting of phytepsin. Phytepsin, as its animal counterparts, possesses a topology typical of all aspartic proteases [[cite:PUB00014083]].</p> <p>In Arabidopsis, there are two phytepsin genes, At1g11910 and At4g04460, but the proteins encoded by them have not been characterized.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aspartic-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Aspartic proteinase 2 [Glycine max] gi|351725345|ref|NP_001237345.1| | 30 | ||
| – | Aspartic protease isoform 2 [Theobroma cacao] gi|508701346|gb|EOX93242.1| | 30 | ||
| – | Aspartic proteinase [Vigna unguiculata] gi|20800441|gb|AAB03843.2| | 32 | ||
| – | Aspartic proteinase; TAIR: AT1G11910.1 aspartic proteinase A1; Swiss-Prot: sp|P42211|ASPRX_ORYSJ Aspartic proteinase; TrEMBL-Plants: tr|A0A0B2SEY7|A0A0B2SEY7_GLYSO Aspartic proteinase; Found in the gene: LotjaGi1g1v0751400 | 30 | ||
| – | Aspartic proteinase; TAIR: AT1G11910.1 aspartic proteinase A1; Swiss-Prot: sp|P42211|ASPRX_ORYSJ Aspartic proteinase; TrEMBL-Plants: tr|A0A0B2SEY7|A0A0B2SEY7_GLYSO Aspartic proteinase; Found in the gene: LotjaGi1g1v0751400 | 30 | ||
| – | Aspartic proteinase; TAIR: AT1G11910.1 aspartic proteinase A1; Swiss-Prot: sp|O65390|APA1_ARATH Aspartic proteinase A1; TrEMBL-Plants: tr|A0A151RMJ6|A0A151RMJ6_CAJCA Aspartic proteinase oryzasin-1; Found in the gene: LotjaGi3g1v0187200 | 30 | ||
| – | Aspartic proteinase; TAIR: AT1G62290.1 Saposin-like aspartyl protease family protein; Swiss-Prot: sp|Q8VYL3|APA2_ARATH Aspartic proteinase A2; TrEMBL-Plants: tr|A0A151SU18|A0A151SU18_CAJCA Aspartic proteinase; Found in the gene: LotjaGi4g1v0012200 | 31 | ||
| – | Aspartic proteinase; TAIR: AT1G62290.1 Saposin-like aspartyl protease family protein; Swiss-Prot: sp|Q8VYL3|APA2_ARATH Aspartic proteinase A2; TrEMBL-Plants: tr|A0A151SU18|A0A151SU18_CAJCA Aspartic proteinase; Found in the gene: LotjaGi4g1v0012200 | 31 | ||
| – | Aspartic proteinase; TAIR: AT1G11910.1 aspartic proteinase A1; Swiss-Prot: sp|P42211|ASPRX_ORYSJ Aspartic proteinase; TrEMBL-Plants: tr|A0A072VYH6|A0A072VYH6_MEDTR Fungal proteinase A, aspartic proteinase superfamily protein; Found in the gene: LotjaGi5g1v0233800 | 31 | ||
| – | Aspartic proteinase; TAIR: AT1G11910.1 aspartic proteinase A1; Swiss-Prot: sp|P42211|ASPRX_ORYSJ Aspartic proteinase; TrEMBL-Plants: tr|A0A072VYH6|A0A072VYH6_MEDTR Fungal proteinase A, aspartic proteinase superfamily protein; Found in the gene: LotjaGi5g1v0233800 | 31 | ||
| – | Aspartic proteinase; TAIR: AT1G11910.1 aspartic proteinase A1; Swiss-Prot: sp|O65390|APA1_ARATH Aspartic proteinase A1; TrEMBL-Plants: tr|I1MFJ1|I1MFJ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0292400 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06098 | CDD | 1 | 9.09 |