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IPR033931 is a PDK1-type, PH domain.
<p>This entry represents the pleckstrin homology (PH) domain from 3-phosphoinositide-dependent protein kinase 1 (PDK1) type proteins. <p>PDK1 plays an important role in insulin and growth factor signalling cascades. It phosphorylates and activates many AGC (cAMP-dependent, cGMP-dependent, protein kinase C (PKC)) family of protein kinases members, including protein kinase B (PKB, also known as Akt), p70 ribosomal S6-kinase (S6K), serum and glucocorticoid responsive kinase (SGK), p90 ribosomal S6 kinase (RSK), and PKC [[cite:PUB00032153]]. PDK1 contains an N-terminal serine/threonine kinase domain followed by a PH domain. Following binding of the PH domain to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, PDK1 activates these enzymes by phosphorylating a Ser/Thr residue in their activation loop. [[cite:PUB00049772], [cite:PUB00081787], [cite:PUB00081788], [cite:PUB00081789]].</p> <p>This superfamily represents the PH domain and structurally related domains.</p> <p>Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [[cite:PUB00014130], [cite:PUB00014131], [cite:PUB00057291]].</p> <p>PH domains have a partly opened β-barrel topology that is capped by an α-helix. The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1) [[cite:PUB00000936]], Shc adaptor and Numb [[cite:PUB00018031]]; to the Ran-binding domain, found in Nup nuclear pore complex and Ranbp1 [[cite:PUB00006171]]; to the Enabled/VASP homology domain 1 (EVH1 domain), found in Enabled, VASP (vasodilator-stimulated phosphoprotein), Homer and WASP actin regulatory protein [[cite:PUB00018222]]; and to the third domain of FERM, found in moesin, radixin, ezrin, merlin and talin [[cite:PUB00029080]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 3-phosphoinositide-dependent protein kinase 1-like isoform X2 [Cicer arietinum] gi|502118222|ref|XP_004496160.1| | 19 | ||
| – | PREDICTED: 3-phosphoinositide-dependent protein kinase 1-like isoform X2 [Cicer arietinum] gi|502118222|ref|XP_004496160.1| | 19 | ||
| – | Kinase-like protein; TAIR: AT5G04510.1 3'-phosphoinositide-dependent protein kinase 1; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 21 | ||
| – | Kinase-like protein; TAIR: AT3G10540.1 3-phosphoinositide-dependent protein kinase; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 17 | ||
| – | Kinase-like protein; TAIR: AT3G10540.1 3-phosphoinositide-dependent protein kinase; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |