Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR039046 is a PDPK1 family.
<p>This family includes 3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) and related kinases from yeast: Pkh1 and Pkh2 from S. cerevisiae, which function similarly to PDK1 [[cite:PUB00088816]], and Ksg1 [[cite:PUB00088817]] and Ppk21 from S. pombe [[cite:PUB00088819]].</p> <p>PDK1 is the kinase responsible for the phosphorylation of PKB/Akt on the activation loop, at threonine 308, which is essential for Akt activation [[cite:PUB00088820], [cite:PUB00088821]]. Beyond Akt, PDK1 is responsible for the phosphorylation of many other AGC kinases including serum/glucocorticoid regulated kinase (SGK) [[cite:PUB00088826]] and the members of protein kinase C (PKC) family [[cite:PUB00088828]]. PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc [[cite:PUB00088824]]. It is a key regulator of cell migration and tumor invasion [[cite:PUB00088823]]. PDK1 binds to the insulin receptor, followed by tyrosine phosphorylation of PDK1 by the insulin receptor, which is necessary for insulin metabolic signaling [[cite:PUB00088830]]. Deficiency of PDK1 in liver results in glucose intolerance [[cite:PUB00088832]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Kinase-like protein; TAIR: AT5G04510.1 3'-phosphoinositide-dependent protein kinase 1; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 21 | ||
| – | Kinase-like protein; TAIR: AT3G10540.1 3-phosphoinositide-dependent protein kinase; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 17 | ||
| – | Kinase-like protein; TAIR: AT3G10540.1 3-phosphoinositide-dependent protein kinase; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |