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IPR039046 is a PDPK1 family.
<p>This family includes 3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) and related kinases from yeast: Pkh1 and Pkh2 from S. cerevisiae, which function similarly to PDK1 [[cite:PUB00088816]], and Ksg1 [[cite:PUB00088817]] and Ppk21 from S. pombe [[cite:PUB00088819]].</p> <p>PDK1 is the kinase responsible for the phosphorylation of PKB/Akt on the activation loop, at threonine 308, which is essential for Akt activation [[cite:PUB00088820], [cite:PUB00088821]]. Beyond Akt, PDK1 is responsible for the phosphorylation of many other AGC kinases including serum/glucocorticoid regulated kinase (SGK) [[cite:PUB00088826]] and the members of protein kinase C (PKC) family [[cite:PUB00088828]]. PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc [[cite:PUB00088824]]. It is a key regulator of cell migration and tumor invasion [[cite:PUB00088823]]. PDK1 binds to the insulin receptor, followed by tyrosine phosphorylation of PDK1 by the insulin receptor, which is necessary for insulin metabolic signaling [[cite:PUB00088830]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Kinase-like protein; TAIR: AT5G04510.1 3'-phosphoinositide-dependent protein kinase 1; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 21 | ||
| – | Kinase-like protein; TAIR: AT3G10540.1 3-phosphoinositide-dependent protein kinase; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 17 | ||
| – | Kinase-like protein; TAIR: AT3G10540.1 3-phosphoinositide-dependent protein kinase; Swiss-Prot: sp|Q9XF67|PDPK1_ARATH 3-phosphoinositide-dependent protein kinase 1; TrEMBL-Plants: tr|A0A0L9TFD6|A0A0L9TFD6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0265800 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |