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IPR033956 is a Translin.
<p>Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse orthologue), is a paralogue of its binding partner protein TRAX (translin-associated factor-X) [[cite:PUB00005776]] and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC) [[cite:PUB00081871]]. DNA damage has been proposed to stimulate transport of Translin into nuclei. It binds to RNA and single-stranded DNA, and its selectivity is modulated by interactions with GTP and TRAX. Translin may also regulate dendritic trafficking of BDNF RNAs as well as function as a key activator of siRNA-mediated silencing in Drosophila [[cite:PUB00081872]]. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis [[cite:PUB00081875], [cite:PUB00081874], [cite:PUB00081876]]; however, their precise role in some of the processes remains unclear.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Single-stranded DNA binding | Interacting selectively and non-covalently with single-stranded DNA. | ||
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Biological process | RNA metabolic process | The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: translin-like [Cicer arietinum] gi|502111191|ref|XP_004493980.1| | 17 | ||
| – | Translin; TAIR: AT2G37020.1 Translin family protein; Swiss-Prot: sp|P79769|TSN_CHICK Translin; TrEMBL-Plants: tr|I3SZY3|I3SZY3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0689500 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd14819 | CDD | 1 | 50.00 |