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IPR016068

Source: InterPro

Description

IPR016068 is a Translin, N-terminal.

<p>Translins are DNA-binding proteins that specifically recognise consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. They seem to recognise single-sranded DNA ends generated by staggered breaks occuring at recombination hot spots [[cite:PUB00005776]].</p> <p>Translin folds into an α-α superhelix, consisting of two curved layers of α/α topology [[cite:PUB00028825], [cite:PUB00037000]]. This structure can be divided into two α-bundle subdomains. This entry represents the N-terminal α bundle subdomain.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0043565
Molecular function Sequence-specific DNA binding Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj0g3v0077759.1
–
Domains
8
Lj0g3v0120679.1
– Translin-associated protein X [Medicago truncatula] gi|357516891|ref|XP_003628734.1|
Domains
12
Lj0g3v0120679.2
– Translin-associated protein X [Medicago truncatula] gi|357516891|ref|XP_003628734.1|
Domains
11
Lj1g3v4590980.1
– PREDICTED: translin-like [Cicer arietinum] gi|502111191|ref|XP_004493980.1|
Domains
17
LotjaGi1g1v0689500.1
– Translin; TAIR: AT2G37020.1 Translin family protein; Swiss-Prot: sp|P79769|TSN_CHICK Translin; TrEMBL-Plants: tr|I3SZY3|I3SZY3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0689500
Domains
18
LotjaGi2g1v0073400.1
– Translin family protein; TAIR: AT2G03780.1 Translin family protein; Swiss-Prot: sp|Q99598|TSNAX_HUMAN Translin-associated protein X; TrEMBL-Plants: tr|I3SA77|I3SA77_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0073400
Domains
13
LotjaGi2g1v0073400.2
– Translin family protein; TAIR: AT2G03780.1 Translin family protein; Swiss-Prot: sp|Q99598|TSNAX_HUMAN Translin-associated protein X; TrEMBL-Plants: tr|I3SA77|I3SA77_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0073400
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd14820 CDD 1 14.29