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IPR035144

Source: InterPro

Description

IPR035144 is a Proteasome subunit alpha 1.

<p>This entry represents the constitutive proteasome subunit alpha 1 [[cite:PUB00085220]], also known as Prosalpha6 (in<i>Drosophila melanogaster</i>) [[cite:PUB00085221]] and Pre5 or alpha 6 (in fungi) [[cite:PUB00085222], [cite:PUB00030848]]. This subunit is replaced in the<i>D. melanogaster</i>spermatoproteasome [[cite:PUB00085221]].</p> <p>The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated α-β-β-α cylinder with a central cavity. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily. Their N-terminal threonine residues are exposed as a nucleophile in peptide bond hydrolysis [[cite:PUB00080970]]. Mammals have 7 alpha and 7 beta proteasome subunits while archaea have one of each.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0019773
Cellular component Proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.
Subterm of
Part of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi5g1v0014300.1
– Proteasome subunit alpha type; TAIR: AT5G42790.1 proteasome alpha subunit F1; Swiss-Prot: sp|P34066|PSA1A_ARATH Proteasome subunit alpha type-1-A; TrEMBL-Plants: tr|A0A0S3RQB5|A0A0S3RQB5_PHAAN Proteasome subunit alpha type; Found in the gene: LotjaGi5g1v0014300
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00