Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR000426

Source: InterPro

Description

IPR000426 is a Proteasome alpha-subunit, N-terminal domain.

<p>The proteasome (or macropain) ([ec:3.4.25.1]) [[cite:PUB00000524], [cite:PUB00000148], [cite:PUB00004123], [cite:PUB00001329], [cite:PUB00005460]] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that is involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway. In eukaryotes the 20S proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700kDa. Proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). The proteasome consists of four stacked rings composed of α/β/β/α subunits. There are seven different alpha subunits and seven different beta subunits [[cite:PUB00030848]]. Three of the seven beta subunits are peptidases, each with a different specificity. Subunit beta1c (MEROPS identifier T01.010) has a preference for cleaving glutaminyl bonds ("peptidyl-glutamyl-like" or "caspase-like"), subunit beta2c (MEROPS identifier T01.011) has a preference for cleaving arginyl and lysyl bonds ("trypsin-like"), and subunit beta5c (MEROPS identifier T01.012) cleaves after hydrophobic amino acids ("chymotrypsin-like") [[cite:PUB00080992]]. The proteasome subunits are related to N-terminal nucleophile hydrolases, and the catalytic subunits have an N-terminal threonine nucleophile.</p> <p>Subunits that belong to the A group are proteins of from 210 to 290 amino acids. They are classified as non-peptidase homologues in MEROPS peptidase family T1 (clan PB(T)).</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004175
Molecular function Endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
Subterm of
GO:0006511
Biological process Ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
Subterm of
GO:0019773
Cellular component Proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.
Subterm of
Part of

Associated Lotus transcripts 32

Transcript Name Description Predicted domains Domain count
Lj0g3v0069859.1
– PREDICTED: proteasome subunit alpha type-7 [Vitis vinifera] gi|225428005|ref|XP_002278162.1|
Domains
15
Lj0g3v0363779.1
– 20S proteasome alpha subunit G1 [Theobroma cacao] gi|508785767|gb|EOY33023.1|
Domains
14
Lj0g3v0363779.2
– PREDICTED: proteasome subunit alpha type-3-like [Cicer arietinum] gi|502091750|ref|XP_004489625.1|
Domains
14
Lj1g3v2375870.1
– PREDICTED: proteasome subunit alpha type-4-like isoform 1 [Glycine max] gi|356496249|ref|XP_003516981.1|
Domains
14
Lj1g3v4916360.1
– PREDICTED: proteasome subunit alpha type-2-A-like [Cicer arietinum] gi|502153994|ref|XP_004509539.1|
Domains
12
Lj2g3v1979680.1
– PREDICTED: proteasome subunit alpha type-7-like [Glycine max] gi|356559270|ref|XP_003547923.1|
Domains
14
Lj5g3v0108300.1
– PREDICTED: proteasome subunit alpha type-1-B-like [Cicer arietinum] gi|502126081|ref|XP_004499172.1|
Domains
15
Lj5g3v2240990.1
– 20S proteasome alpha subunit E2 isoform 2 [Theobroma cacao] gi|508780133|gb|EOY27389.1|
Domains
15
LotjaGi1g1v0445900.1
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|I3S0L1|I3S0L1_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0445900
Domains
14
LotjaGi1g1v0445900.2
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|I3S0L1|I3S0L1_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0445900
Domains
14
LotjaGi1g1v0445900.3
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|I3S0L1|I3S0L1_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0445900
Domains
14
LotjaGi1g1v0445900.4
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|I3S0L1|I3S0L1_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0445900
Domains
14
LotjaGi1g1v0445900.5
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|I3S0L1|I3S0L1_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0445900
Domains
14
LotjaGi1g1v0445900.6
– Proteasome subunit alpha type; TAIR: AT4G15165.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; Swiss-Prot: sp|F4JJE5|PSA4B_ARATH Putative proteasome subunit alpha type-4-B; TrEMBL-Plants: tr|I3S0L1|I3S0L1_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0445900
Domains
13
LotjaGi1g1v0445900.7
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|I3S0L1|I3S0L1_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0445900
Domains
14
LotjaGi1g1v0767900.1
– Proteasome subunit alpha type; TAIR: AT1G16470.1 proteasome subunit PAB1; Swiss-Prot: sp|O23708|PSA2A_ARATH Proteasome subunit alpha type-2-A; TrEMBL-Plants: tr|I3SFE3|I3SFE3_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0767900
Domains
15
LotjaGi1g1v0767900.2
– Proteasome subunit alpha type; TAIR: AT1G16470.1 proteasome subunit PAB1; Swiss-Prot: sp|A2YVR7|PSA2_ORYSI Proteasome subunit alpha type-2; TrEMBL-Plants: tr|A0A0S3TCR9|A0A0S3TCR9_PHAAN Proteasome subunit alpha type; Found in the gene: LotjaGi1g1v0767900
Domains
15
LotjaGi2g1v0410600.1
– Proteasome subunit alpha type; TAIR: AT5G66140.1 proteasome alpha subunit D2; Swiss-Prot: sp|Q9SXU1|PSA7_CICAR Proteasome subunit alpha type-7; TrEMBL-Plants: tr|A0A0L9TPU8|A0A0L9TPU8_PHAAN Proteasome subunit alpha type; Found in the gene: LotjaGi2g1v0410600
Domains
15
LotjaGi3g1v0135900.1
– Proteasome subunit alpha type; TAIR: AT1G16470.1 proteasome subunit PAB1; Swiss-Prot: sp|O23708|PSA2A_ARATH Proteasome subunit alpha type-2-A; TrEMBL-Plants: tr|I3SFE3|I3SFE3_MEDTR Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0135900
Domains
15
LotjaGi3g1v0198400.1
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|A0A0B2P141|A0A0B2P141_GLYSO Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0198400
Domains
14
LotjaGi3g1v0198400.2
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|A0A0B2P141|A0A0B2P141_GLYSO Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0198400
Domains
14
LotjaGi3g1v0198400.3
– Proteasome subunit alpha type; TAIR: AT3G22110.1 20S proteasome alpha subunit C1; Swiss-Prot: sp|O81148|PSA4A_ARATH Proteasome subunit alpha type-4-A; TrEMBL-Plants: tr|A0A0B2P141|A0A0B2P141_GLYSO Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0198400
Domains
14
LotjaGi3g1v0198400.4
– Proteasome subunit alpha type; TAIR: AT4G15165.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; Swiss-Prot: sp|F4JJE5|PSA4B_ARATH Putative proteasome subunit alpha type-4-B; TrEMBL-Plants: tr|A0A0B2P141|A0A0B2P141_GLYSO Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0198400
Domains
13
LotjaGi3g1v0323300.1
– Proteasome subunit alpha type; TAIR: AT5G35590.1 proteasome alpha subunit A1; Swiss-Prot: sp|O48551|PSA6_SOYBN Proteasome subunit alpha type-6; TrEMBL-Plants: tr|I3T518|I3T518_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0323300
Domains
15
LotjaGi3g1v0323300.2
– Proteasome subunit alpha type; TAIR: AT5G35590.1 proteasome alpha subunit A1; Swiss-Prot: sp|O48551|PSA6_SOYBN Proteasome subunit alpha type-6; TrEMBL-Plants: tr|I3T518|I3T518_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0323300
Domains
15
LotjaGi4g1v0130000.1
– Proteasome subunit alpha type; TAIR: AT5G66140.1 proteasome alpha subunit D2; Swiss-Prot: sp|Q9SXU1|PSA7_CICAR Proteasome subunit alpha type-7; TrEMBL-Plants: tr|A0A0L9TPU8|A0A0L9TPU8_PHAAN Proteasome subunit alpha type; Found in the gene: LotjaGi4g1v0130000
Domains
15
LotjaGi5g1v0014300.1
– Proteasome subunit alpha type; TAIR: AT5G42790.1 proteasome alpha subunit F1; Swiss-Prot: sp|P34066|PSA1A_ARATH Proteasome subunit alpha type-1-A; TrEMBL-Plants: tr|A0A0S3RQB5|A0A0S3RQB5_PHAAN Proteasome subunit alpha type; Found in the gene: LotjaGi5g1v0014300
Domains
16
LotjaGi5g1v0345600.1
– Proteasome subunit alpha type; TAIR: AT3G14290.1 20S proteasome alpha subunit E2; Swiss-Prot: sp|Q9LSU1|PSA5_ORYSJ Proteasome subunit alpha type-5; TrEMBL-Plants: tr|I3S0W6|I3S0W6_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi5g1v0345600
Domains
15
LotjaGi5g1v0345600.2
– Proteasome subunit alpha type; TAIR: AT3G14290.1 20S proteasome alpha subunit E2; Swiss-Prot: sp|Q9LSU1|PSA5_ORYSJ Proteasome subunit alpha type-5; TrEMBL-Plants: tr|I3S0W6|I3S0W6_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi5g1v0345600
Domains
15
LotjaGi6g1v0082700.1
– Proteasome subunit alpha type; TAIR: AT2G27020.2 20S proteasome alpha subunit G1; Swiss-Prot: sp|O23715|PSA3_ARATH Proteasome subunit alpha type-3; TrEMBL-Plants: tr|I3STC4|I3STC4_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi6g1v0082700
Domains
15
LotjaGi6g1v0082700.2
– Proteasome subunit alpha type; TAIR: AT2G27020.1 20S proteasome alpha subunit G1; Swiss-Prot: sp|O24362|PSA3_SPIOL Proteasome subunit alpha type-3; TrEMBL-Plants: tr|I3STC4|I3STC4_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi6g1v0082700
Domains
15
LotjaGi6g1v0082700.3
– Proteasome subunit alpha type; TAIR: AT2G27020.2 20S proteasome alpha subunit G1; Swiss-Prot: sp|O24362|PSA3_SPIOL Proteasome subunit alpha type-3; TrEMBL-Plants: tr|I3STC4|I3STC4_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi6g1v0082700
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03751 CDD 1 3.13