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IPR035543 is a Translation initiation factor eIF-2B subunit epsilon, N-terminal.
<p>This is the N-terminal domain of epsilon subunit of the eukaryotic translation initiation factor 2B (eIF-2B). eIF-2B is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, generating active eIF2-GTP complex. EIF2B is a complex multimeric protein consisting of five subunits named alpha, beta, gamma, delta and epsilon. Subunit epsilon shares sequence similarity with gamma subunit, and with a family of bifunctional nucleotide-binding enzymes such as ADP-glucose pyrophosphorylase, suggesting that epsilon subunit may play roles in nucleotide binding activity. In yeast, eIF2B gamma enhances the activity of eIF2B-epsilon leading to the idea that these subunits form the catalytic subcomplex [[cite:PUB00085565], [cite:PUB00085566]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Translation initiation factor eIF-2B subunit epsilon; TAIR: AT2G34970.1 Trimeric LpxA-like enzyme; Swiss-Prot: sp|P56287|EI2BE_SCHPO Probable translation initiation factor eIF-2B subunit epsilon; TrEMBL-Plants: tr|V7BQ00|V7BQ00_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0309800 | 25 | ||
| – | Translation initiation factor eIF-2B subunit epsilon; TAIR: AT2G34970.1 Trimeric LpxA-like enzyme; Swiss-Prot: sp|P56287|EI2BE_SCHPO Probable translation initiation factor eIF-2B subunit epsilon; TrEMBL-Plants: tr|V7BQ00|V7BQ00_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0309800 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |