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IPR035793 is a GDAP2, macro domain.
<p>This macro domain is found in proteins similar to human GDAP2, the ganglioside induced differentiation associated protein 2, whose gene is expressed at a higher level in differentiated Neuro2a cells compared with non-differentiated cells [[cite:PUB00086216]]. GDAP2 contains an N-terminal macro domain and a C-terminal Sec14p-like lipid binding domain. It is specifically expressed in brain and testis.</p> <p>The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ADP-ribose as a ligand. Previously identified as displaying an Appr-1"-p (ADP-ribose-1"-monophosphate) processing activity, the macro domain may play roles in distinct ADP-ribose pathways, such as the ADP-ribosylation of proteins, an important post-translational modification which occurs in DNA repair, transcription, chromatin biology, and long-term memory formation, among other processes [[cite:PUB00021032]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Appr-1-P processing enzyme family protein; TAIR: AT1G69340.1 appr-1-p processing enzyme family protein; Swiss-Prot: sp|A7T167|GDAP2_NEMVE Protein GDAP2 homolog; TrEMBL-Plants: tr|V7CH06|V7CH06_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0297800 | 20 | ||
| – | Appr-1-P processing enzyme family protein; TAIR: AT1G69340.1 appr-1-p processing enzyme family protein; Swiss-Prot: sp|A7T167|GDAP2_NEMVE Protein GDAP2 homolog; TrEMBL-Plants: tr|A0A072UEM6|A0A072UEM6_MEDTR Appr-1-P processing enzyme family protein; Found in the gene: LotjaGi2g1v0297800 | 19 | ||
| – | Appr-1-P processing enzyme family protein; TAIR: AT1G69340.1 appr-1-p processing enzyme family protein; Swiss-Prot: sp|A7T167|GDAP2_NEMVE Protein GDAP2 homolog; TrEMBL-Plants: tr|V7CH06|V7CH06_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0297800 | 19 | ||
| – | Appr-1-P processing enzyme family protein; TAIR: AT1G69340.1 appr-1-p processing enzyme family protein; Swiss-Prot: sp|A7T167|GDAP2_NEMVE Protein GDAP2 homolog; TrEMBL-Plants: tr|V7CH06|V7CH06_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0297800 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |