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IPR036104

Source: InterPro

Description

IPR036104 is a Bifunctional nuclease superfamily.

<p>The bifunctional nuclease (BFN) domain is specific to bacteria and plant organisms. It has both RNase and DNase activities [[cite:PUB00057454]].</p> <p>The dimer of the BFN domain forms a wedge, each monomer being a basic triangular shape. The BFN domain is composed of an eight-stranded, distorted β-sheet consisting of a four-stranded, antiparallel β-sheet (B1, B2, B3, B8), and a four-stranded mixed β-sheet (B4, B5, B6, B7). The sheets are intercalated by three short α-helices (H1, H3, H4), while a longer α-helix (H2) forms the central core of the dimer interface [[cite:PUB00029328]].</p> <p>Some proteins known to contain a BFN domain are listed below:</p> <ul> <li>Thermotoga maritima TM0160, a conserved hypothetical protein.</li> <li>Plant bifunctional nuclease in basal defense response (BBD) proteins, regulators in abscisic acid (ABA)-mediated defense responses.</li> </ul> <p>This entry represents the BFN superfamily.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004518
Molecular function Nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0421900.1
– Bifunctional nuclease 1; TAIR: AT1G75380.1 bifunctional nuclease in basal defense response 1; Swiss-Prot: sp|Q9FWS6|BBD1_ARATH Bifunctional nuclease 1; TrEMBL-Plants: tr|B7FJ72|B7FJ72_MEDTR Wound-responsive family protein; Found in the gene: LotjaGi1g1v0421900
Domains
10
LotjaGi2g1v0377000.1
– Bifunctional nuclease; TAIR: AT5G66050.1 Wound-responsive family protein; Swiss-Prot: sp|Q93VH2|BBD2_ARATH Bifunctional nuclease 2; TrEMBL-Plants: tr|G7JYS6|G7JYS6_MEDTR Wound-responsive family protein; Found in the gene: LotjaGi2g1v0377000
Domains
8
LotjaGi5g1v0012600.1
– Bifunctional nuclease 1; TAIR: AT1G75380.1 bifunctional nuclease in basal defense response 1; Swiss-Prot: sp|Q9FWS6|BBD1_ARATH Bifunctional nuclease 1; TrEMBL-Plants: tr|I3T9N9|I3T9N9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0012600
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF103256 SUPERFAMILY 1 33.33