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IPR036135 is a MoeA, N-terminal and linker domain superfamily.
<p>This entry represents the N-terminal and linker domains of the MoeA protein. One of these two structural domains contains the conserved DGXA motif. These two domains are found in proteins involved in biosynthesis of molybdopterin cofactor. MoeA facilitates molybdenum incorporation at low levels of molybdate [[cite:PUB00016026]]. However, the exact molecular function of this region is uncertain [[cite:PUB00034758], [cite:PUB00016176]].</p> <p>The majority of molybdenum-containing enzymes utilise a molybdenum cofactor (MoCF or Moco) consisting of a Mo atom coordinated via a cis-dithiolene moiety to molybdopterin (MPT). MoCF is ubiquitous in nature, and the pathway for MoCF biosynthesis is conserved in all three domains of life. MoCF-containing enzymes function as oxidoreductases in carbon, nitrogen, and sulphur metabolism [[cite:PUB00034759], [cite:PUB00034757]].</p> <p>The MoeA structure has a complex fold made of bifurcated and coiled β-sheets.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Molybdopterin cofactor biosynthetic process | The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Molybdopterin biosynthesis protein CNX1; TAIR: AT5G20990.1 molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1); Swiss-Prot: sp|Q39054|CNX1_ARATH Molybdopterin biosynthesis protein CNX1; TrEMBL-Plants: tr|A0A0B2S2T0|A0A0B2S2T0_GLYSO Molybdopterin biosynthesis protein CNX1; Found in the gene: LotjaGi1g1v0059300 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00887 | CDD | 1 | 100.00 |