Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR036219 is a Translation elongation factor eEF-1beta-like superfamily.
<p>Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [[cite:PUB00033953], [cite:PUB00033952], [cite:PUB00033951]]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.</p> <p>Elongation factor EF1B (also known as EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to regenerate EF1A from its inactive form (EF1A-GDP) to its active form (EF1A-GTP). EF1A is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF1B is more complex in eukaryotes than in bacteria, and can consist of three subunits: EF1B-alpha (or EF-1beta), EF1B-gamma (or EF-1gamma) and EF1B-beta (or EF-1delta) [[cite:PUB00033953]].</p> <p>This entry represents the guanine nucleotide exchange domain of the beta (EF-1beta, also known as EF1B-alpha) and delta (EF-1delta, also known as EF1B-beta) chains of EF1B proteins from eukaryotes and archaea. The beta and delta chains have exchange activity, which mainly resides in their homologous guanine nucleotide exchange domains, found in the C-terminal region of the peptides. Their N-terminal regions may be involved in interactions with the gamma chain (EF-1gamma).</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Elongation factor 1-beta; TAIR: AT2G18110.1 Translation elongation factor EF1B/ribosomal protein S6 family protein; Swiss-Prot: sp|P93447|EF1D_PIMBR Elongation factor 1-delta; TrEMBL-Plants: tr|I3T5W1|I3T5W1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0222400 | 18 | ||
– | Elongation factor 1-beta 1; TAIR: AT5G12110.1 elongation factor 1-beta 1; Swiss-Prot: sp|Q84WM9|EF1B1_ARATH Elongation factor 1-beta 1; TrEMBL-Plants: tr|I3SIG0|I3SIG0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0187900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 50.00 |