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IPR036982 is a Deoxyhypusine synthase superfamily.
<p>Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see [interpro:IPR001884]), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS, [ec:2.5.1.46]). The enzyme catalyses the following reaction:</p> <p> <reaction> Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusine </reaction> </p> <p>The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [[cite:PUB00005808]]. The structure is known for this enzyme in complex with its NAD<sup>+</sup>cofactor, it is a tetramer of four identical subunits arranged with 222 symmetry where each subunit contains a Rossmann fold [[cite:PUB00005808]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Biological process | Peptidyl-lysine modification to peptidyl-hypusine | The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Deoxyhypusine synthase; TAIR: AT5G05920.1 deoxyhypusine synthase; Swiss-Prot: sp|Q9FI94|DHYS_ARATH Deoxyhypusine synthase; TrEMBL-Plants: tr|C6ZS19|C6ZS19_SOYBN Dhs1; Found in the gene: LotjaGi1g1v0610600 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF52467 | SUPERFAMILY | 1 | 100.00 |