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IPR037227 is a Endoribonuclease EndoU-like.
<p>This entry represents the EndoU-like endoribonucleases from a variety of organisms that range from viruses to humans. The founding member XendoU is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [[cite:PUB00086627], [cite:PUB00039850]]. The human EndoU, known as PP11, is a endoribonuclease with placental tissue specificity [[cite:PUB00086626]].</p> <p>In human SARS coronavirus, EndoU (also known as NSP15) is part of the replicase-transcriptase complex that plays important roles in virus replication and transcription. NSP15 is a Uridylate-specific endoribonuclease that cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA [[cite:PUB00094089]], either upstream or downstream of uridylates, at GUU or GU to produce molecules with 2',3'-cyclic phosphate ends [[cite:PUB00086628]]. PUN RNA is a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP) [[cite:PUB00094089]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Poly(U)-specific endoribonuclease-B-like protein; TAIR: AT4G17100.1 poly(U)-specific endoribonuclease-B protein; Swiss-Prot: sp|B1WBB4|ENDUB_XENLA Poly(U)-specific endoribonuclease-B; TrEMBL-Plants: tr|A0A072UPG4|A0A072UPG4_MEDTR Poly(U)-specific endoribonuclease-B-like protein; Found in the gene: LotjaGi4g1v0192700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |