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IPR018998 is a EndoU ribonuclease, C-terminal.
<p>This entry represents the EndoU domain found at the C-terminal of EndoU endoribonucleases, which carries out a conserved RNA processing function. The EndoU domain cleaves RNA at uridylates and release 2',3'-cyclic phosphodiester ends. The EndoU domain is an α/β domain, that contains nine α-helices and three antiparallel β-sheets; the latter are clustered on one side of the domain, whereas the α-helices are largely on the other side [[cite:PUB00039850]]. It contains a conserved trio of catalytic residues, two histidines and a lysine.</p> <p>EndoU is a family of metal-dependent endoribonucleases that is broadly conserved among eukaryotes [[cite:PUB00100908], [cite:PUB00100912]]. EndoU family members have RNA-binding and endoribonuclease activities and appear to be involved in many aspects of biology, including small nucleolar RNA biogenesis, endoplasmic reticulum (ER) network formation, immune response, and neurodegeneration:</p> <ul> <li>Xenopus laevis endoribonuclease XendoU is responsible for processing the intron encoded U16 and U86 small nucleolar RNAs (snoRNAs) [[cite:PUB00039850], [cite:PUB00100909], [cite:PUB00086627]].</li> <li>Human EndoU, also known as PP11 (placental protein 11), has an endoribonuclease activity with placental tissue specificity [[cite:PUB00086626], [cite:PUB00100913], [cite:PUB00086628]].</li> <li>Drosophila melanogaster CG2145 and DendoU endoribonucleases [[cite:PUB00100910]].</li> <li>Caenorhabditis elegans endu-2 regulates nucleotide metabolism and germ cell proliferation in response to nucleotide imbalance and other genotoxic stress [[cite:PUB00100911]].</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Endoribonuclease activity | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: poly(U)-specific endoribonuclease-B-like [Cicer arietinum] gi|502152665|ref|XP_004509033.1| | 5 | ||
| – | PREDICTED: poly(U)-specific endoribonuclease-B-like [Cicer arietinum] gi|502152665|ref|XP_004509033.1| | 6 | ||
| – | Poly(U)-specific endoribonuclease-B-like protein; TAIR: AT4G17100.1 poly(U)-specific endoribonuclease-B protein; Swiss-Prot: sp|B1WBB4|ENDUB_XENLA Poly(U)-specific endoribonuclease-B; TrEMBL-Plants: tr|A0A072UPG4|A0A072UPG4_MEDTR Poly(U)-specific endoribonuclease-B-like protein; Found in the gene: LotjaGi4g1v0192700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |