Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR037256 is a ASC domain superfamily.
<p>Association with the SNF1 complex (ASC) domain is found in the Sip1/Sip2/Gal83/AMPKbeta subunits of the SNF1/AMP-activated protein kinase (AMPK) complex [[cite:PUB00072630]]. SNF1/AMPK are heterotrimeric enzymes composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit [[cite:PUB00071601]]. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83 [[cite:PUB00008604], [cite:PUB00071596]]. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits. The ASC domain is required for interaction with Snf4 [[cite:PUB00072630], [cite:PUB00071601]].</p> <p>The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [[cite:PUB00042779], [cite:PUB00071595]]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources.</p> <p>Structurally, this domain comprises three short helices and 3-stranded meander β-sheet which makes extensive intermolecular interactions.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | SNF1-related protein kinase regulatory subunit beta-2; TAIR: AT4G16360.1 SNF1-related protein kinase regulatory subunit beta-2; Swiss-Prot: sp|Q9SCY5|KINB2_ARATH SNF1-related protein kinase regulatory subunit beta-2; TrEMBL-Plants: tr|K7KBS0|K7KBS0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0004800 | 11 | ||
| – | SNF1-related protein kinase regulatory subunit beta-2; TAIR: AT4G16360.1 SNF1-related protein kinase regulatory subunit beta-2; Swiss-Prot: sp|Q9SCY5|KINB2_ARATH SNF1-related protein kinase regulatory subunit beta-2; TrEMBL-Plants: tr|A0A0L9UUZ6|A0A0L9UUZ6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0004800 | 11 | ||
| – | SNF1-related protein kinase regulatory subunit beta-1; TAIR: AT5G21170.1 5'-AMP-activated protein kinase beta-2 subunit protein; Swiss-Prot: sp|Q84VQ1|KINB1_ARATH SNF1-related protein kinase regulatory subunit beta-1; TrEMBL-Plants: tr|A0A151U1N8|A0A151U1N8_CAJCA SNF1-related protein kinase regulatory subunit beta-1; Found in the gene: LotjaGi1g1v0055200 | 17 | ||
| – | SNF1-related protein kinase regulatory subunit beta-2; TAIR: AT2G28060.1 5'-AMP-activated protein kinase beta-2 subunit protein; Swiss-Prot: sp|Q9ZUU8|KINB3_ARATH SNF1-related protein kinase regulatory subunit beta-3; TrEMBL-Plants: tr|I3SNK1|I3SNK1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0487800 | 10 | ||
| – | SNF1-related protein kinase regulatory subunit beta-2; TAIR: AT4G16360.1 SNF1-related protein kinase regulatory subunit beta-2; Swiss-Prot: sp|Q9SCY5|KINB2_ARATH SNF1-related protein kinase regulatory subunit beta-2; TrEMBL-Plants: tr|I1MFR8|I1MFR8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0283000 | 17 | ||
| – | SNF1-related protein kinase regulatory subunit beta-2; TAIR: AT4G16360.1 SNF1-related protein kinase regulatory subunit beta-2; Swiss-Prot: sp|Q9SCY5|KINB2_ARATH SNF1-related protein kinase regulatory subunit beta-2; TrEMBL-Plants: tr|I1MFR8|I1MFR8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0283000 | 17 | ||
| – | SNF1-related protein kinase regulatory subunit beta-2; TAIR: AT4G16360.1 SNF1-related protein kinase regulatory subunit beta-2; Swiss-Prot: sp|Q9SCY5|KINB2_ARATH SNF1-related protein kinase regulatory subunit beta-2; TrEMBL-Plants: tr|I3S3S8|I3S3S8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0283000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02859 | CDD | 1 | 14.29 |