Description

IPR038357 is a KEN domain superfamily.

<p>The proteins listed below share a common architecture with a protein kinase homology domain (see [prositedoc:PDOC00100]) followed by an ~135-residue globular kinase-extension nuclease (KEN) domain made of eight helices [[cite:PUB00049391]]:</p> <ul> <li>Mammalian 2-5A-dependent RNase or RNase L (EC 3.1.26.-), an interferon-induced enzyme implicated in both the molecular mechanisms of interferon action and the fundamental control of RNA stability. 2-5A-dependent RNase is a unique enzyme in that it requires 2-5A, unusual oligoadenylates with 2',5'-phosphodiester linkages. RNase L is catalytically active only after binding to an unusual activator molecule containing a 5'-phosphorylated 2', 5'-linked oligoadenylate (2-5A), in the N-terminal half. RNase L consists of three domains, namely the N-terminal ankyrin repeat domain (see [prositedoc:PDOC50088]), the protein kinase homology domain, and the C-terminal KEN domain [[cite:PUB00052589], [cite:PUB00038080], [cite:PUB00052590]].</li> <li>Eukaryotic Ire1/Ern1, an ancient transmembrane sensor of endoplasmic reticulum (ER) stress with dual protein kinase and ribonuclease activities. In response to ER stress Ire1/Ern1 catalyzes the splicing of target mRNAs in a spliceosome-independent manner. Ire1/Ern1 is a type 1 transmembrane receptor consisting of an N-terminal ER luminal domain, a transmembrane segment and a cytoplasmic region. The cytoplasmic region encompasses a protein kinase domain followed by a C-terminal KEN domain [[cite:PUB00049391], [cite:PUB00012627]].</li> </ul> <p>The dimerisation of the kinase domain activates the ribonuclease function of the KEN domain [[cite:PUB00049391]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: