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IPR010513 is a KEN domain.
<p>The proteins listed below share a common architecture with a protein kinase homology domain (see [prositedoc:PDOC00100]) followed by an ~135-residue globular kinase-extension nuclease (KEN) domain made of eight helices [[cite:PUB00049391]]:</p> <ul> <li>Mammalian 2-5A-dependent RNase or RNase L (EC 3.1.26.-), an interferon-induced enzyme implicated in both the molecular mechanisms of interferon action and the fundamental control of RNA stability. 2-5A-dependent RNase is a unique enzyme in that it requires 2-5A, unusual oligoadenylates with 2',5'-phosphodiester linkages. RNase L is catalytically active only after binding to an unusual activator molecule containing a 5'-phosphorylated 2', 5'-linked oligoadenylate (2-5A), in the N-terminal half. RNase L consists of three domains, namely the N-terminal ankyrin repeat domain (see [prositedoc:PDOC50088]), the protein kinase homology domain, and the C-terminal KEN domain [[cite:PUB00052589], [cite:PUB00038080], [cite:PUB00052590]].</li> <li>Eukaryotic Ire1/Ern1, an ancient transmembrane sensor of endoplasmic reticulum (ER) stress with dual protein kinase and ribonuclease activities. In response to ER stress Ire1/Ern1 catalyzes the splicing of target mRNAs in a spliceosome-independent manner. Ire1/Ern1 is a type 1 transmembrane receptor consisting of an N-terminal ER luminal domain, a transmembrane segment and a cytoplasmic region. The cytoplasmic region encompasses a protein kinase domain followed by a C-terminal KEN domain [[cite:PUB00049391], [cite:PUB00012627]].</li> </ul> <p>The dimerisation of the kinase domain activates the ribonuclease function of the KEN domain [[cite:PUB00049391]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. | ||
| Biological process | MRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: serine/threonine-protein kinase ppk4-like [Cicer arietinum] gi|502161785|ref|XP_004512283.1| | 35 | ||
| – | PREDICTED: serine/threonine-protein kinase ppk4-like [Cicer arietinum] gi|502153776|ref|XP_004509458.1| | 29 | ||
| – | Kinase, putative; TAIR: AT2G17520.1 Endoribonuclease/protein kinase IRE1-like protein; Swiss-Prot: sp|Q9C5S2|IRE1A_ARATH Serine/threonine-protein kinase/endoribonuclease IRE1a; TrEMBL-Plants: tr|G7K1A9|G7K1A9_MEDTR Endoribonuclease/kinase IRE1-like protein; Found in the gene: LotjaGi2g1v0353800 | 37 | ||
| – | Kinase, putative; TAIR: AT2G17520.1 Endoribonuclease/protein kinase IRE1-like protein; Swiss-Prot: sp|Q9C5S2|IRE1A_ARATH Serine/threonine-protein kinase/endoribonuclease IRE1a; TrEMBL-Plants: tr|K7LEW9|K7LEW9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0134700 | 32 | ||
| – | Kinase, putative; TAIR: AT2G17520.1 Endoribonuclease/protein kinase IRE1-like protein; Swiss-Prot: sp|Q7XIT1|IRE1_ORYSJ Serine/threonine-protein kinase/endoribonuclease IRE1; TrEMBL-Plants: tr|A0A0D9WYP0|A0A0D9WYP0_9ORYZ Uncharacterized protein; Found in the gene: LotjaGi5g1v0083000_LC | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF56112 | SUPERFAMILY | 1 | 20.00 |