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IPR038358 is a VPS28, N-terminal domain superfamily.
<p>The Endosomal Sorting Complex Required for Transport (ESCRT) complexes form the machinery driving protein sorting from endosomes to lysosomes. ESCRT complexes are central to receptor down-regulation, lysosome biogenesis, and budding of HIV. Yeast ESCRT-I consists of three protein subunits, Vps23, Vps28, and Vps37. In humans, ESCRT-I comprises TSG101, VPS28, and one of four potential human VPS37 homologues. The main role of ESCRT-I is to recognise ubiquitinated cargo via the UEV domain of the VPS23/TSG101 subunit. The assembly of the ESCRT-I complex is directed by the C-terminal steadiness box (SB) of VPS23, the N-terminal half of VPS28, and the C-terminal half of VPS37. The structure is primarily composed of three long, parallel helical hairpins, each corresponding to a different subunit. The additional domains and motifs extending beyond the core serve as gripping tools for ESCRT-I critical functions [[cite:PUB00039953], [cite:PUB00040552]].</p> <p>This superfamily represents the N-terminal domain of the Vacuolar protein sorting-associated 28 (VPS28).</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Vacuolar sorting-associated protein 28-like protein; TAIR: AT4G05000.1 Vacuolar protein sorting-associated protein VPS28 family protein; Swiss-Prot: sp|Q9S9T7|VP282_ARATH Vacuolar protein sorting-associated protein 28 homolog 2; TrEMBL-Plants: tr|G7JRS3|G7JRS3_MEDTR Vacuolar protein sorting-associated protein VPS28, putative; Found in the gene: LotjaGi4g1v0050200 | 16 | ||
| – | Vacuolar sorting-associated protein 28-like protein; TAIR: AT4G05000.1 Vacuolar protein sorting-associated protein VPS28 family protein; Swiss-Prot: sp|Q9S9T7|VP282_ARATH Vacuolar protein sorting-associated protein 28 homolog 2; TrEMBL-Plants: tr|G7JRS3|G7JRS3_MEDTR Vacuolar protein sorting-associated protein VPS28, putative; Found in the gene: LotjaGi4g1v0050200 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF140427 | SUPERFAMILY | 1 | 50.00 |