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IPR038492 is a GBBH-like, N-terminal domain superfamily.
<p>Gamma-butyrobetaine hydroxylase (GBBH), also known as gamma-butyrobetaine dioxygenase, is an alpha-ketoglutarate-dependent dioxygenase that catalyses the biosynthesis of L-carnitine by hydroxylation of gamma-butyrobetaine (GBB). GBBH is a dimeric enzyme. The monomer consists of a catalytic double-stranded β-helix domain and a smaller N-terminal domain. The N-terminal domain has a bound Zn ion, which is coordinated by three cysteines and one histidine. The N-terminal domain facilitates the assembly of a symmetric head-to-tail dimer formation through the interface with the C-terminal domain of the other monomer [[cite:PUB00075680], [cite:PUB00103931]].</p> <p>This domain superfamily is also found in another hydroxylase of the biosynthetic pathway of L-carnitine, the first enzyme of the pathway, known as trimethyllysine dioxygenase (TMLD). Like GBBH, TMLD is a non-heme ferrous-iron dioxygenase that requires alpha-ketoglutarate, Fe2+, and molecular oxygen as cofactors [[cite:PUB00084964]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cytosolic Fe-S cluster assembly factor NBP35; TAIR: AT3G24430.1 ATP binding protein; Swiss-Prot: sp|Q6STH5|HF101_ARATH Fe-S cluster assembly factor HCF101, chloroplastic; TrEMBL-Plants: tr|I1L4F4|I1L4F4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0212500 | 21 | ||
| – | Cytosolic Fe-S cluster assembly factor NBP35; TAIR: AT3G24430.1 ATP binding protein; Swiss-Prot: sp|Q6STH5|HF101_ARATH Fe-S cluster assembly factor HCF101, chloroplastic; TrEMBL-Plants: tr|G7KNK7|G7KNK7_MEDTR Nucleotide-binding protein; Found in the gene: LotjaGi2g1v0212500 | 21 | ||
| – | Myb domain protein; TAIR: AT3G27340.1 Myb domain protein; Swiss-Prot: sp|A1W6E1|SYC_ACISJ Cysteine--tRNA ligase; TrEMBL-Plants: tr|I3TA82|I3TA82_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0157700 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR35303:SF5 | PANTHER | 1 | 33.33 |