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IPR038887

Source: InterPro

Description

IPR038887 is a Dehydrodolichyl diphosphate synthase complex subunit Nus1.

<p>Nus1 (also known as Nogo-B receptor, NgBR) is a subunit of cis-prenyltransferase, a enzymatic activity critical for the synthesis of dolichol, an obligate carrier of oligosaccharides for protein glycosylation reactions [[cite:PUB00088515]]. It plays an essential role in angiogenesis during wound healing and embryonic development. In mice, it is essential for endothelial cell glycosylation and vascular development [[cite:PUB00088516]]. In zebrafish, it is bound by Nogo-B ligand that activates Akt pathway to stimulate endothelial cell chemotaxis [[cite:PUB00088517]]. In humans, it is involved in breast cancer cell growth through modulating Ras signaling [[cite:PUB00088518]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0019408
Biological process Dolichol biosynthetic process The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.
Subterm of
GO:1904423
Cellular component Dehydrodolichyl diphosphate synthase complex A protein complex which is capable of dehydrodolichyl diphosphate synthase activity.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0451200.1
– Dehydrodolichyl diphosphate synthase complex subunit NUS1; TAIR: AT1G11755.1 Undecaprenyl pyrophosphate synthetase family protein; Swiss-Prot: sp|Q96E22|NGBR_HUMAN Dehydrodolichyl diphosphate synthase complex subunit NUS1; TrEMBL-Plants: tr|G7K548|G7K548_MEDTR Undecaprenyl pyrophosphate synthetase family protein; Found in the gene: LotjaGi2g1v0451200
Domains
9
LotjaGi5g1v0075400.1
– Dehydrodolichyl diphosphate synthase complex subunit NUS1; TAIR: AT1G11755.1 Undecaprenyl pyrophosphate synthetase family protein; Swiss-Prot: sp|Q96E22|NGBR_HUMAN Dehydrodolichyl diphosphate synthase complex subunit NUS1; TrEMBL-Plants: tr|A0A0B2RPB0|A0A0B2RPB0_GLYSO Nogo-B receptor; Found in the gene: LotjaGi5g1v0075400
Domains
9
LotjaGi5g1v0075400.2
– Dehydrodolichyl diphosphate synthase complex subunit NUS1; TAIR: AT1G11755.1 Undecaprenyl pyrophosphate synthetase family protein; Swiss-Prot: sp|Q96E22|NGBR_HUMAN Dehydrodolichyl diphosphate synthase complex subunit NUS1; TrEMBL-Plants: tr|I1JAN3|I1JAN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0075400
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 33.33