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IPR039143 is a Glucosamine 6-phosphate N-acetyltransferase-like.
<p>This family groups acetyltransferases with broad specificity from bacteria, archaea and eukaryotes, including glucosamine 6-phosphate N-acetyltransferase (GNPNAT1; [ec:2.3.1.4]) from mammals and plants, and GCN5-related N-acetyltransferase 3 (GNAT3) from plants.</p> <p>GNPNAT1 is a component in the pathway for UDP-N-acetyl-alpha-D-glucosamine biosynthesis. GNPNAT1 transfers the acetyl group from acetyl-CoA to D-glucosamine 6-phosphate to generate N-acetyl-D-glucosamine 6-phosphate [[cite:PUB00051171]]. The enzyme contains a GNAT domain and is naturally a homodimer [[cite:PUB00051171]]. The enzyme from <i>Aspergillus fumigatus</i>, the causative agent of aspergillosis, is a potential drug target [[cite:PUB00049950]].</p> <p>GNAT3 is an acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA) and epsilon-lysine acetylation (KA), possibly with a low efficiency or toward specific plastid substrates [[cite:PUB00103909]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glucosamine 6-phosphate N-acetyltransferase activity | Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+). | ||
| Biological process | UDP-N-acetylglucosamine biosynthetic process | The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glucosamine 6-phosphate N-acetyltransferase; TAIR: AT5G15770.1 glucose-6-phosphate acetyltransferase 1; Swiss-Prot: sp|Q9LFU9|GNA1_ARATH Glucosamine 6-phosphate N-acetyltransferase; TrEMBL-Plants: tr|G7KQU8|G7KQU8_MEDTR Glucosamine 6-phosphate N-acetyltransferase; Found in the gene: LotjaGi1g1v0013200 | 10 | ||
| – | Acyl-CoA N-acyltransferases (NAT) superfamily protein; TAIR: AT4G19985.2 Acyl-CoA N-acyltransferases (NAT) superfamily protein; Swiss-Prot: sp|P51192|YCF52_PORPU Uncharacterized N-acetyltransferase ycf52; TrEMBL-Plants: tr|A0A0L9UE84|A0A0L9UE84_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0303700 | 3 | ||
| – | N-acetyltransferase, putative; TAIR: AT4G19985.1 Acyl-CoA N-acyltransferases (NAT) superfamily protein; Swiss-Prot: sp|P51192|YCF52_PORPU Uncharacterized N-acetyltransferase ycf52; TrEMBL-Plants: tr|G7J9R3|G7J9R3_MEDTR Acetyltransferase (GNAT) domain protein; Found in the gene: LotjaGi1g1v0303700 | 10 | ||
| – | Glucosamine 6-phosphate N-acetyltransferase; TAIR: AT5G15770.1 glucose-6-phosphate acetyltransferase 1; Swiss-Prot: sp|Q9LFU9|GNA1_ARATH Glucosamine 6-phosphate N-acetyltransferase; TrEMBL-Plants: tr|G7KQU8|G7KQU8_MEDTR Glucosamine 6-phosphate N-acetyltransferase; Found in the gene: LotjaGi1g1v0741000 | 10 | ||
| – | Glucosamine 6-phosphate N-acetyltransferase; TAIR: AT5G15770.1 glucose-6-phosphate acetyltransferase 1; Swiss-Prot: sp|Q9LFU9|GNA1_ARATH Glucosamine 6-phosphate N-acetyltransferase; TrEMBL-Plants: tr|G7KQU8|G7KQU8_MEDTR Glucosamine 6-phosphate N-acetyltransferase; Found in the gene: LotjaGi1g1v0741000 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04301 | CDD | 1 | 20.00 |