Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR039373 is a Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like.
<p>This entry includes glutamate carboxypeptidase 2 (FOLH1) and its homologues from peptidase family M28 subfamily B. Not all members of this subfamily are peptidases, and non-peptidase homologues include transferrin receptor proteins (TFRC).</p> <p>FOLH1 is a zinc-dependent carboxypeptidase that also acts as a folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase). It has a preference for tri-alpha-glutamate peptides [[cite:PUB00050638]]. It is required for the uptake of folate in the intestine, and in the brain modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), releasing glutamate. Two zinc ions are bound per molecule [[cite:PUB00039905]].</p> <p>TFRC acts as a lipid sensor, controlling the fusion of mitochondria by modulating the activation of the JNK pathway [[cite:PUB00153046]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glutamate carboxypeptidase 2; TAIR: AT5G19740.1 Peptidase M28 family protein; Swiss-Prot: sp|Q9M1S8|GCP2_ARATH Probable glutamate carboxypeptidase 2; TrEMBL-Plants: tr|A0A0B2S7Y3|A0A0B2S7Y3_GLYSO Putative glutamate carboxypeptidase 2; Found in the gene: LotjaGi2g1v0225800 | 26 | ||
| – | Glutamate carboxypeptidase 2; TAIR: AT5G19740.1 Peptidase M28 family protein; Swiss-Prot: sp|Q9M1S8|GCP2_ARATH Probable glutamate carboxypeptidase 2; TrEMBL-Plants: tr|I1J4H3|I1J4H3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0225900 | 25 | ||
| – | Glutamate carboxypeptidase 2; TAIR: AT5G19740.1 Peptidase M28 family protein; Swiss-Prot: sp|Q9M1S8|GCP2_ARATH Probable glutamate carboxypeptidase 2; TrEMBL-Plants: tr|I1J4H4|I1J4H4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0225900 | 19 | ||
| – | Glutamate carboxypeptidase 2; TAIR: AT5G19740.1 Peptidase M28 family protein; Swiss-Prot: sp|Q9M1S8|GCP2_ARATH Probable glutamate carboxypeptidase 2; TrEMBL-Plants: tr|A0A0B2S7Y3|A0A0B2S7Y3_GLYSO Putative glutamate carboxypeptidase 2; Found in the gene: LotjaGi2g1v0225900 | 25 | ||
| – | Glutamate carboxypeptidase 2; TAIR: AT5G19740.1 Peptidase M28 family protein; Swiss-Prot: sp|Q9M1S8|GCP2_ARATH Probable glutamate carboxypeptidase 2; TrEMBL-Plants: tr|A0A0B2S7Y3|A0A0B2S7Y3_GLYSO Putative glutamate carboxypeptidase 2; Found in the gene: LotjaGi2g1v0226100 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF47672 | SUPERFAMILY | 1 | 20.00 |