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IPR039663 is a AIP/AIPL1/TTC9.
<p>Proteins in this entry have an N-terminal FKBP-type peptidyl-prolyl cis-trans isomerase domain followed by a C-terminal tetratricopeptide repeat-containing domain. Included in this entry are: aryl-hydrocarbon-interacting protein-like 1 (AIPL1), which is associated with inherited blindness and interacts with cell cycle regulator protein NUB1 [[cite:PUB00089922]]; and AH receptor-interacting protein (AIP), which interacts with the tyrosine kinase receptor RET [[cite:PUB00089923]], and mutations in AIP are associated with familial isolated pituitary adenomas [[cite:PUB00089924]].</p> <p>This entry also matches Tetratricopeptide repeat protein 9 (TTC9). TTC9 contains tetratricopeptide repeat (TPR) domains constituted of the 34 amino acid consensus motif present in various number of tandem repeats [[cite:PUB00101448]]. Tetratricopeptide repeat protein 9A (TTC9A) is involved anxiety-like behaviors through estrogen action in female mice [[cite:PUB00101446], [cite:PUB00101447]], and is thought to play a role in cancer cell invasion and metastasis [[cite:PUB00101448]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Peptidylprolyl isomerase; TAIR: AT3G21640.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9LDC0|FKB42_ARATH Peptidyl-prolyl cis-trans isomerase FKBP42; TrEMBL-Plants: tr|A0A0B2RKD3|A0A0B2RKD3_GLYSO Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0550000 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |