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IPR001179

Source: InterPro

Description

IPR001179 is a FKBP-type peptidyl-prolyl cis-trans isomerase domain.

<p>FKBP-type peptidylprolyl isomerases ([ec:5.2.1.8]) in vertebrates, are receptors for the two immunosuppressants, FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides. These proteins are found in a variety of organisms [[cite:PUB00083171]].</p> <p>This entry represents a domain found in FKBP-type peptidylprolyl isomerases.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003755
Molecular function Peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Subterm of

Associated Lotus transcripts 58

Transcript Name Description Predicted domains Domain count
Lj0g3v0091679.1
– PREDICTED: peptidyl-prolyl isomerase PASTICCINO1-like [Glycine max] gi|356504332|ref|XP_003520950.1|
Domains
20
Lj0g3v0109499.1
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like [Glycine max] gi|356558981|ref|XP_003547780.1|
Domains
9
Lj0g3v0110919.1
– Peptidyl-prolyl cis-trans isomerase FKBP4 [Medicago truncatula] gi|357492297|ref|XP_003616437.1|
Domains
9
Lj0g3v0242939.1
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like isoform X1 [Cicer arietinum] gi|502140944|ref|XP_004504385.1|
Domains
8
Lj0g3v0250799.1
– FK506-binding protein [Medicago truncatula] gi|357470491|ref|XP_003605530.1|
Domains
9
Lj0g3v0296959.1
– PREDICTED: LOW QUALITY PROTEIN: probable FKBP-type peptidyl-prolyl cis-trans isomerase 1, chloroplastic-like [Glycine max] gi|356548345|ref|XP_003542563.1|
Domains
8
Lj1g3v1733540.1
– 70 kDa peptidyl-prolyl isomerase [Medicago truncatula] gi|357437549|ref|XP_003589050.1|
Domains
19
Lj1g3v3329120.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP19, chloroplastic-like [Cicer arietinum] gi|502102164|ref|XP_004491988.1|
Domains
15
Lj1g3v3329120.3
– PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP19, chloroplastic-like [Cicer arietinum] gi|502102164|ref|XP_004491988.1|
Domains
14
Lj1g3v3388970.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP18, chloroplastic-like isoform X2 [Cicer arietinum] gi|502130996|ref|XP_004500840.1|
Domains
8
Lj1g3v3580610.1
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like [Glycine max] gi|356527318|ref|XP_003532258.1|
Domains
18
Lj1g3v4081900.1
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like [Glycine max] gi|356503354|ref|XP_003520475.1|
Domains
10
Lj1g3v4081900.2
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like [Glycine max] gi|356503354|ref|XP_003520475.1|
Domains
19
Lj2g3v1203450.1
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like [Glycine max] gi|356558981|ref|XP_003547780.1|
Domains
8
Lj2g3v2103080.1
– FK506-binding protein [Medicago truncatula] gi|357481299|ref|XP_003610935.1|
Domains
10
Lj3g3v0525150.1
– PREDICTED: FKBP-type peptidyl-prolyl cis-trans isomerase 6, chloroplastic-like [Glycine max] gi|356520790|ref|XP_003529043.1|
Domains
8
Lj3g3v0718250.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP62-like [Cicer arietinum] gi|502155914|ref|XP_004510236.1|
Domains
20
Lj3g3v0718320.1
– PREDICTED: FK506-binding protein 2-like [Cicer arietinum] gi|502155917|ref|XP_004510237.1|
Domains
17
Lj3g3v3336130.1
– PREDICTED: probable FKBP-type peptidyl-prolyl cis-trans isomerase 2, chloroplastic-like [Glycine max] gi|356538867|ref|XP_003537922.1|
Domains
15
Lj3g3v3336130.2
– PREDICTED: probable FKBP-type peptidyl-prolyl cis-trans isomerase 2, chloroplastic-like [Glycine max] gi|356538867|ref|XP_003537922.1|
Domains
14
Lj3g3v3690010.1
– PREDICTED: 42 kDa peptidyl-prolyl isomerase-like [Glycine max] gi|356542700|ref|XP_003539804.1|
Domains
22
Lj4g3v0189820.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP13, chloroplastic-like [Cicer arietinum] gi|502141777|ref|XP_004504633.1|
Domains
13
Lj4g3v2575050.1
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like [Glycine max] gi|356528282|ref|XP_003532733.1|
Domains
18
Lj4g3v2576100.1
– PREDICTED: 70 kDa peptidyl-prolyl isomerase-like isoform X2 [Cicer arietinum] gi|502140947|ref|XP_004504386.1|
Domains
18
Lj4g3v3114660.3
– PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP17-2, chloroplastic-like [Cicer arietinum] gi|502138113|ref|XP_004503291.1|
Domains
10
Lj5g3v0711050.1
– PREDICTED: 39 kDa FK506-binding nuclear protein-like [Glycine max] gi|356537045|ref|XP_003537041.1|
Domains
11
Lj6g3v2193600.1
– PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP12-like [Cicer arietinum] gi|502077284|ref|XP_004485605.1|
Domains
9
LotjaGi1g1v0088900.1
– Peptidylprolyl isomerase; TAIR: AT3G55520.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9M2S7|FK201_ARATH Peptidyl-prolyl cis-trans isomerase FKBP20-1; TrEMBL-Plants: tr|I3S2Q0|I3S2Q0_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0088900
Domains
9
LotjaGi1g1v0088900.2
– Peptidylprolyl isomerase; TAIR: AT3G55520.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9M2S7|FK201_ARATH Peptidyl-prolyl cis-trans isomerase FKBP20-1; TrEMBL-Plants: tr|I3S2Q0|I3S2Q0_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0088900
Domains
9
LotjaGi1g1v0552400.1
– Peptidylprolyl isomerase; TAIR: AT5G13410.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9LYR5|FKB19_ARATH Peptidyl-prolyl cis-trans isomerase FKBP19, chloroplastic; TrEMBL-Plants: tr|G7KXR3|G7KXR3_MEDTR Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0552400
Domains
13
LotjaGi1g1v0568400.1
– Peptidylprolyl isomerase; TAIR: AT1G20810.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9LM71|FKB18_ARATH Peptidyl-prolyl cis-trans isomerase FKBP18, chloroplastic; TrEMBL-Plants: tr|I3SZ21|I3SZ21_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0568400
Domains
6
LotjaGi1g1v0592300.1
– Peptidylprolyl isomerase; TAIR: AT3G25230.1 rotamase FKBP 1; Swiss-Prot: sp|Q38931|FKB62_ARATH Peptidyl-prolyl cis-trans isomerase FKBP62; TrEMBL-Plants: tr|I3T6U6|I3T6U6_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0592300
Domains
18
LotjaGi1g1v0592300.2
– Peptidylprolyl isomerase; TAIR: AT3G25230.1 rotamase FKBP 1; Swiss-Prot: sp|Q38931|FKB62_ARATH Peptidyl-prolyl cis-trans isomerase FKBP62; TrEMBL-Plants: tr|I3T6U6|I3T6U6_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0592300
Domains
18
LotjaGi1g1v0592300.3
– Peptidylprolyl isomerase; TAIR: AT3G25230.1 rotamase FKBP 1; Swiss-Prot: sp|Q38931|FKB62_ARATH Peptidyl-prolyl cis-trans isomerase FKBP62; TrEMBL-Plants: tr|I3T6U6|I3T6U6_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0592300
Domains
18
LotjaGi1g1v0592300.4
– Peptidylprolyl isomerase; TAIR: AT3G25230.1 rotamase FKBP 1; Swiss-Prot: sp|Q38931|FKB62_ARATH Peptidyl-prolyl cis-trans isomerase FKBP62; TrEMBL-Plants: tr|I3T6U6|I3T6U6_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0592300
Domains
17
LotjaGi1g1v0657600.1
– Peptidylprolyl isomerase; TAIR: AT5G48570.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9FJL3|FKB65_ARATH Peptidyl-prolyl cis-trans isomerase FKBP65; TrEMBL-Plants: tr|A0A151TAL9|A0A151TAL9_CAJCA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0657600
Domains
16
LotjaGi1g1v0657600.2
– Peptidylprolyl isomerase; TAIR: AT5G48570.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9FJL3|FKB65_ARATH Peptidyl-prolyl cis-trans isomerase FKBP65; TrEMBL-Plants: tr|A0A151TAL9|A0A151TAL9_CAJCA Peptidylprolyl isomerase; Found in the gene: LotjaGi1g1v0657600
Domains
16
LotjaGi2g1v0026800.1
– Peptidylprolyl isomerase; TAIR: AT4G25340.1 FK506 BINDING PROTEIN 53; Swiss-Prot: sp|Q93ZG9|FKB53_ARATH Peptidyl-prolyl cis-trans isomerase FKBP53; TrEMBL-Plants: tr|A0A072UIJ4|A0A072UIJ4_MEDTR Peptidylprolyl isomerase; Found in the gene: LotjaGi2g1v0026800
Domains
11
LotjaGi2g1v0026800.2
– Peptidylprolyl isomerase; TAIR: AT4G25340.1 FK506 BINDING PROTEIN 53; Swiss-Prot: sp|Q93ZG9|FKB53_ARATH Peptidyl-prolyl cis-trans isomerase FKBP53; TrEMBL-Plants: tr|A0A072UIJ4|A0A072UIJ4_MEDTR Peptidylprolyl isomerase; Found in the gene: LotjaGi2g1v0026800
Domains
11
LotjaGi2g1v0445300.1
– Peptidylprolyl isomerase; TAIR: AT4G25340.1 FK506 BINDING PROTEIN 53; Swiss-Prot: sp|Q93ZG9|FKB53_ARATH Peptidyl-prolyl cis-trans isomerase FKBP53; TrEMBL-Plants: tr|A0A151SCX5|A0A151SCX5_CAJCA Peptidylprolyl isomerase; Found in the gene: LotjaGi2g1v0445300
Domains
16
LotjaGi2g1v0445300.2
– Peptidylprolyl isomerase; TAIR: AT4G25340.1 FK506 BINDING PROTEIN 53; Swiss-Prot: sp|Q93ZG9|FKB53_ARATH Peptidyl-prolyl cis-trans isomerase FKBP53; TrEMBL-Plants: tr|A0A151SCX5|A0A151SCX5_CAJCA Peptidylprolyl isomerase; Found in the gene: LotjaGi2g1v0445300
Domains
14
LotjaGi3g1v0065500.1
– Peptidylprolyl isomerase; TAIR: AT3G60370.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q0WRJ7|FK202_ARATH Peptidyl-prolyl cis-trans isomerase FKBP20-2, chloroplastic; TrEMBL-Plants: tr|I3SJZ8|I3SJZ8_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0065500
Domains
9
LotjaGi3g1v0089100.1
– Peptidylprolyl isomerase; TAIR: AT5G48580.1 FK506- and rapamycin-binding protein 15 kD-2; Swiss-Prot: sp|Q41649|FKB15_VICFA FK506-binding protein 2; TrEMBL-Plants: tr|I3SJ25|I3SJ25_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0089100
Domains
15
LotjaGi3g1v0089300.1
– Peptidylprolyl isomerase; TAIR: AT3G25230.1 rotamase FKBP 1; Swiss-Prot: sp|Q38931|FKB62_ARATH Peptidyl-prolyl cis-trans isomerase FKBP62; TrEMBL-Plants: tr|A0A151T0E7|A0A151T0E7_CAJCA Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0089300
Domains
20
LotjaGi3g1v0089300.2
– Peptidylprolyl isomerase; TAIR: AT3G25230.1 rotamase FKBP 1; Swiss-Prot: sp|Q38931|FKB62_ARATH Peptidyl-prolyl cis-trans isomerase FKBP62; TrEMBL-Plants: tr|A0A151T0E7|A0A151T0E7_CAJCA Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0089300
Domains
19
LotjaGi3g1v0220500.1
– Peptidylprolyl isomerase; TAIR: AT3G54010.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q7DMA9|PAS1_ARATH Peptidyl-prolyl cis-trans isomerase PASTICCINO1; TrEMBL-Plants: tr|I1JLY3|I1JLY3_SOYBN Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0220500
Domains
19
LotjaGi3g1v0220500.2
– Peptidylprolyl isomerase; TAIR: AT3G54010.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q7DMA9|PAS1_ARATH Peptidyl-prolyl cis-trans isomerase PASTICCINO1; TrEMBL-Plants: tr|I1JLY3|I1JLY3_SOYBN Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0220500
Domains
19
LotjaGi3g1v0501400.1
– Peptidylprolyl isomerase; TAIR: AT2G43560.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|O22870|FK163_ARATH Peptidyl-prolyl cis-trans isomerase FKBP16-3, chloroplastic; TrEMBL-Plants: tr|I1LJL8|I1LJL8_SOYBN Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0501400
Domains
13
LotjaGi3g1v0501400.2
– Peptidylprolyl isomerase; TAIR: AT2G43560.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|O22870|FK163_ARATH Peptidyl-prolyl cis-trans isomerase FKBP16-3, chloroplastic; TrEMBL-Plants: tr|I1LJL8|I1LJL8_SOYBN Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0501400
Domains
14
LotjaGi3g1v0550000.1
– Peptidylprolyl isomerase; TAIR: AT3G21640.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9LDC0|FKB42_ARATH Peptidyl-prolyl cis-trans isomerase FKBP42; TrEMBL-Plants: tr|A0A0B2RKD3|A0A0B2RKD3_GLYSO Peptidylprolyl isomerase; Found in the gene: LotjaGi3g1v0550000
Domains
22
LotjaGi4g1v0018800.1
– Peptidylprolyl isomerase; TAIR: AT5G45680.1 FK506-binding protein 13; Swiss-Prot: sp|Q9SCY2|FKB13_ARATH Peptidyl-prolyl cis-trans isomerase FKBP13, chloroplastic; TrEMBL-Plants: tr|A0A072UQ15|A0A072UQ15_MEDTR Peptidylprolyl isomerase; Found in the gene: LotjaGi4g1v0018800
Domains
12
LotjaGi4g1v0368800.1
– Peptidylprolyl isomerase; TAIR: AT5G48570.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9FJL3|FKB65_ARATH Peptidyl-prolyl cis-trans isomerase FKBP65; TrEMBL-Plants: tr|A0A072TTW4|A0A072TTW4_MEDTR Peptidylprolyl isomerase; Found in the gene: LotjaGi4g1v0368800
Domains
18
LotjaGi4g1v0400600.1
– Peptidylprolyl isomerase; TAIR: AT4G39710.1 FK506-binding protein 16-2; Swiss-Prot: sp|Q9SCY3|PNSL4_ARATH Photosynthetic NDH subunit of lumenal location 4, chloroplastic; TrEMBL-Plants: tr|I3T1B8|I3T1B8_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi4g1v0400600
Domains
14
LotjaGi5g1v0034800.1
– Peptidylprolyl isomerase; TAIR: AT3G25230.1 rotamase FKBP 1; Swiss-Prot: sp|Q38931|FKB62_ARATH Peptidyl-prolyl cis-trans isomerase FKBP62; TrEMBL-Plants: tr|G7IBB7|G7IBB7_MEDTR Peptidylprolyl isomerase; Found in the gene: LotjaGi5g1v0034800
Domains
16
LotjaGi5g1v0088700.1
– Peptidylprolyl isomerase; TAIR: AT3G10060.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q9SR70|FK164_ARATH Peptidyl-prolyl cis-trans isomerase FKBP16-4, chloroplastic; TrEMBL-Plants: tr|I3S072|I3S072_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi5g1v0088700
Domains
7
LotjaGi5g1v0091700.1
– Peptidylprolyl isomerase; TAIR: AT4G19830.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|O81864|FK171_ARATH Peptidyl-prolyl cis-trans isomerase FKBP17-1, chloroplastic; TrEMBL-Plants: tr|A0A151U3F2|A0A151U3F2_CAJCA Peptidylprolyl isomerase; Found in the gene: LotjaGi5g1v0091700
Domains
9
LotjaGi6g1v0139600.1
– Peptidylprolyl isomerase; TAIR: AT4G26555.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q944B0|FK161_ARATH Peptidyl-prolyl cis-trans isomerase FKBP16-1, chloroplastic; TrEMBL-Plants: tr|A0A0L9TF03|A0A0L9TF03_PHAAN Peptidylprolyl isomerase; Found in the gene: LotjaGi6g1v0139600
Domains
14
LotjaGi6g1v0350000.1
– Peptidylprolyl isomerase; TAIR: AT5G64350.1 FK506-binding protein 12; Swiss-Prot: sp|O04287|FKB12_VICFA Peptidyl-prolyl cis-trans isomerase FKBP12; TrEMBL-Plants: tr|I3S3Y9|I3S3Y9_LOTJA Peptidylprolyl isomerase; Found in the gene: LotjaGi6g1v0350000
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 1.72