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IPR039672 is a Lactose permease-like.
<p>This family includes lactose permease (LacY) and its homologues that are members of the sodium:galactoside symporter (TC 2.A.2) family. LacY is found in Firmicute bacteria such as<i>Streptococcus thermophilus</i>, and is required for transport of beta-galactosides into the cell. Cations are co-transported. LacY contains a PTS EIIA type-1 domain, which may be regulatory. It is an integral membrane protein with many transmembrane regions [[cite:PUB00089937]]. Other homologues in this family include the melibiose carrier protein (MelB) from<i>Escherichia coli</i>, which is required for the transport of melibiose and other galactosides [[cite:PUB00089938]]; glucuronide carrier protein (UidB or GusB), also from<i>E. coli</i>, which transports glucuronide (but is inactive in some strains) [[cite:PUB00089939]]; and isoprimeverose transporter (XylP) from<i>Lactobacillus pentosus</i>, which transports isoprimeverose [[cite:PUB00089940]]. A human member of this family, MFSD12, has been recently characterised as a transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation [[cite:PUB00100737]]. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation [[cite:PUB00100737]]. In non-pigmented cells, it catalyses the import of cysteine into lysosomes [[cite:PUB00100737]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Carbohydrate transport | The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. | ||
| Molecular function | Symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Major facilitator superfamily protein; TAIR: AT3G60070.1 Major facilitator superfamily protein; Swiss-Prot: sp|Q6NUT3|MFS12_HUMAN Major facilitator superfamily domain-containing protein 12; TrEMBL-Plants: tr|A2Q3C2|A2Q3C2_MEDTR C19orf28 protein, related; Found in the gene: LotjaGi3g1v0128600 | 12 | ||
| – | Major facilitator superfamily protein; TAIR: AT3G60070.1 Major facilitator superfamily protein; Swiss-Prot: sp|Q6NUT3|MFS12_HUMAN Major facilitator superfamily domain-containing protein 12; TrEMBL-Plants: tr|A2Q3C2|A2Q3C2_MEDTR C19orf28 protein, related; Found in the gene: LotjaGi3g1v0128600 | 12 | ||
| – | Major facilitator superfamily protein; TAIR: AT3G60070.1 Major facilitator superfamily protein; Swiss-Prot: sp|Q6NUT3|MFS12_HUMAN Major facilitator superfamily domain-containing protein 12; TrEMBL-Plants: tr|A2Q3C2|A2Q3C2_MEDTR C19orf28 protein, related; Found in the gene: LotjaGi3g1v0128600 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd17491 | CDD | 1 | 33.33 |