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IPR039722

Source: InterPro

Description

IPR039722 is a Nonsense-mediated mRNA decay protein 3.

<p>This entry includes nonsense-mediated mRNA decay protein 3 (Upf3) and its homologues. In budding yeasts, Upf3 is involved in the nonsense-mediated mRNA decay (NMD) pathway [[cite:PUB00090013]]. Human Upf3a and Upf3b are components of the exon-junction complex (EJC), which promotes nonsense-mediated mRNA decay (NMD) and regulate translation efficiency [[cite:PUB00084767]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000184
Biological process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0336800.1
– Regulator of nonsense transcripts UPF3 protein; TAIR: AT1G33980.1 Smg-4/UPF3 family protein; Swiss-Prot: sp|Q9FVW4|RENT3_ARATH Regulator of nonsense transcripts UPF3; TrEMBL-Plants: tr|A0A151RFI8|A0A151RFI8_CAJCA Regulator of nonsense transcripts 3A; Found in the gene: LotjaGi3g1v0336800
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00