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IPR039757 is a Eukaryotic translation initiation factor 2D.
<p>Proteins in this entry contain at least an N-terminal PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain and a C-terminal SUI1 domain. Proteins with this architecture include: <ul> <li>Eukaryotic translation initiation factor 2D (EIF2D; formerly and erroneously known as ligatin): a factor that initiates translation by delivering tRNA to the P-site, where the initiating AUG codon binds, of the eukaryotic ribosome in a GTP-independent manner [[cite:PUB00090065]]. EIF2D recruits aminoacylated initiator tRNA (Met-tRNA(Met)(i)) to 40S/mRNA complexes and promotes release of deacylated tRNA and mRNA from recycled 40S subunits after ABCE1-mediated dissociation of post-termination ribosomes [[cite:PUB00090066]].</li> <li>Translation machinery-associated protein 64 (Tma64) from the yeast<i>Saccharomyces cerevisiae</i>, which is uncharacterized but also interacts with the 40S ribosomal subunit [[cite:PUB00035474]].</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Formation of translation preinitiation complex | The joining of the small ribosomal subunit, ternary complex, and mRNA. | ||
| Molecular function | Translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|P0CL18|EIF2D_RABIT Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|I1LVH4|I1LVH4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0055100 | 23 | ||
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|P0CL18|EIF2D_RABIT Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|I1LVH4|I1LVH4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0055100 | 23 | ||
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|Q5PPG7|EIF2D_RAT Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|A0A151RMC0|A0A151RMC0_CAJCA Ligatin; Found in the gene: LotjaGi3g1v0055100 | 12 | ||
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|Q5RA63|EIF2D_PONAB Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|G7JKR1|G7JKR1_MEDTR Eukaryotic translation initiation factor SUI1-like protein; Found in the gene: LotjaGi3g1v0055100 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |