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IPR039781 is a Rad21/Rec8-like protein.
<p>Rad21/Rec8 like proteins mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex [[cite:PUB00008651]]. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation [[cite:PUB00008652]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. | ||
| Cellular component | Cohesin complex | A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Sister chromatid cohesion 1 protein; TAIR: AT5G16270.1 sister chromatid cohesion 1 protein 4; Swiss-Prot: sp|Q8W1Y0|SSC14_ARATH Sister chromatid cohesion 1 protein 4; TrEMBL-Plants: tr|A0A0B2S710|A0A0B2S710_GLYSO Sister chromatid cohesion 1 protein 3; Found in the gene: LotjaGi1g1v0488400 | 12 | ||
| – | Sister chromatid cohesion 1 protein; TAIR: AT5G40840.1 Rad21/Rec8-like family protein; Swiss-Prot: sp|Q9FQ20|SCC12_ARATH Sister chromatid cohesion 1 protein 2; TrEMBL-Plants: tr|G7L499|G7L499_MEDTR Sister chromatid cohesion 1 protein; Found in the gene: LotjaGi1g1v0620400 | 13 | ||
| – | Sister chromatid cohesion 1 protein; TAIR: AT3G59550.1 Rad21/Rec8-like family protein; Swiss-Prot: sp|Q9FQ19|SCC13_ARATH Sister chromatid cohesion 1 protein 3; TrEMBL-Plants: tr|A0A1J7GHV5|A0A1J7GHV5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0125000 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |