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IPR040007 is a THO complex subunit 2.
THO/TREX, a nuclear protein complex conserved from yeast to humans, plays an important role in mRNP biogenesis connecting transcription elongation, mRNA export and preventing genetic instability. THO could be relevant to different mRNA processing steps, including the 3'-end formation, transcript release and export [[PMID:22207203]]. This entry represents the Tho2 subunit of the THO/TREX complex.
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | THO complex | The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. | ||
| Biological process | MRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. | ||
| Biological process | MRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | THO complex subunit 2; TAIR: AT1G24706.7 THO2; Swiss-Prot: sp|F4IAT2|THOC2_ARATH THO complex subunit 2; TrEMBL-Plants: tr|I1K5H3|I1K5H3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0459500 | 11 | ||
| – | THO complex subunit 2; TAIR: AT1G24706.7 THO2; Swiss-Prot: sp|F4IAT2|THOC2_ARATH THO complex subunit 2; TrEMBL-Plants: tr|I1K5H3|I1K5H3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0459500 | 11 | ||
| – | THO complex subunit 2; TAIR: AT1G24706.7 THO2; Swiss-Prot: sp|F4IAT2|THOC2_ARATH THO complex subunit 2; TrEMBL-Plants: tr|I1K5H3|I1K5H3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0459500 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |