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IPR040053

Source: InterPro

Description

IPR040053 is a Josephin-1/2.

<p>Josephin proteins 1 and 2 are deubiquitinating enzymes (DUBs; peptidase family C86) that contain the Josephin domain, characteristic of the MJD family of DUBs. Josephin-1 (JOSD1) releases 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains, provided it is monoubiquitinated itself. Josephin-2 (JOSD2) releases 'Lys-63'-linked poly-ubiquitin chains, but does not require ubiquitination to be active. Ubiquitinated JOSD1 is localized to the plasma membrane, whereas JOSD2 is cytoplasmic [[cite:PUB00090467]]. Josephin-like proteins are also found in Arabidopsis thaliana and Drosophila melanogaster.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004843
Molecular function Thiol-dependent ubiquitin-specific protease activity Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0122700.1
– Josephin-like protein; TAIR: AT2G29640.1 JOSEPHIN-like protein; Swiss-Prot: sp|O82391|JOSL_ARATH Josephin-like protein; TrEMBL-Plants: tr|A0A151U0W8|A0A151U0W8_CAJCA Josephin-like protein; Found in the gene: LotjaGi1g1v0122700
Domains
9
LotjaGi1g1v0122700.2
– Josephin-like protein; TAIR: AT2G29640.1 JOSEPHIN-like protein; Swiss-Prot: sp|O82391|JOSL_ARATH Josephin-like protein; TrEMBL-Plants: tr|A0A151U0W8|A0A151U0W8_CAJCA Josephin-like protein; Found in the gene: LotjaGi1g1v0122700
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SM01246 SMART 1 50.00