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IPR040661 is a Leucine zipper with capping helix domain.
<p>This domain is found at the C-terminal region of Hop2 and Mnd1 proteins. In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex. Hop2 (for homologous pairing; also known as TBPIP) is expressed specifically during meiosis, same as Mnd1 (for meiotic nuclear divisions 1). The C-terminal region of both Hop2 and Mnd1, folds into three α-helices that are interrupted by two short non-helical regions. These α-helices of the two proteins together form a parallel coiled coil that provides the major interface for heterodimer formation. The non-helical regions form substantially kinked junctions between adjacent leucine zippers: the LZ1-LZ2 and LZ2-LZ3 junctions.This domain is the C-terminal segment of Hop2 and Mnd1 which folds back onto the C-terminal leucine zipper (LZ3) to form a helical bundle-like structure, hence designated LZ3wCH (for LZ3 with capping helices). The LZ3wCH region plays a role in interacting with the Dmc1 nucleofilament [[cite:PUB00091209]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Meiotic nuclear division protein 1 homolog; TAIR: AT4G29170.1 Mnd1 family protein; Swiss-Prot: sp|Q8GYD2|MND1_ARATH Meiotic nuclear division protein 1 homolog; TrEMBL-Plants: tr|I1J4E4|I1J4E4_SOYBN Meiotic nuclear division protein 1 homolog; Found in the gene: LotjaGi2g1v0228800 | 8 | ||
| – | Homologous-pairing protein 2 like; TAIR: AT1G13330.1 Tat-binding protein 1(Tbp-1)-interacting protein (TBPIP); Swiss-Prot: sp|Q9FX64|HOP2_ARATH Homologous-pairing protein 2 homolog; TrEMBL-Plants: tr|A0A0L9UTJ7|A0A0L9UTJ7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0278700 | 9 | ||
| – | Homologous-pairing protein 2 like; TAIR: AT1G13330.1 Tat-binding protein 1(Tbp-1)-interacting protein (TBPIP); Swiss-Prot: sp|Q9FX64|HOP2_ARATH Homologous-pairing protein 2 homolog; TrEMBL-Plants: tr|A0A0L9UTJ7|A0A0L9UTJ7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0278700 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF46785 | SUPERFAMILY | 1 | 33.33 |