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IPR040813 is a Small RNA 2'-O-methyltransferase Hen1, La-motif C-terminal domain.
<p>RNA silencing is a conserved regulatory mechanism in fungi, plants and animals that regulates gene expression and defence against viruses and transgenes. A conserved S-adenosyl-l-methionine-dependent RNA methyltransferase, HUA ENHANCER 1 (HEN1), and its homologues are responsible for 2'-O-methylation on the 3' terminal nucleotide of microRNAs and small interfering RNAs (siRNAs). The 2'-O-methylation protects miRNAs and siRNAs from 3'-end uridylation and 3'-to-5' exonuclease-mediated degradation. This domain lies on the C-terminal region of the La-motif domain found in HEN1 [[cite:PUB00091278]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Small RNA 2'-O-methyltransferase; TAIR: AT4G20910.1 double-stranded RNA binding protein-related / DsRBD protein-like protein; Swiss-Prot: sp|Q9C5Q8|HEN1_ARATH Small RNA 2'-O-methyltransferase; TrEMBL-Plants: tr|I1K2Z2|I1K2Z2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0026400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54768 | SUPERFAMILY | 1 | 100.00 |