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IPR040961

Source: InterPro

Description

IPR040961 is a Cop9 signalosome subunit 5 C-terminal domain.

<p>The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that resembles the 19S lid of the 26S proteasome, plays a central role in the regulation of the E3-cullin RING ubiquitin ligases (CRLs) [[cite:PUB00065946]]. The catalytic activity of the CSN complex is carried by subunit 5 (CSN5), also known as c-Jun activation domain-binding protein-1 (Jab1) [[cite:PUB00065946]]. This entry is the C-terminal domain found in CSN5 proteins. CSN5, whose two C-terminal helices form an antiparallel hairpin, inserts its final C-terminal helix (helix II) into the central CSN6 framework at the core of the bundle. Deletion of the C-terminal helices has a pronounced effect on CSN integrity [[cite:PUB00091374]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0393500.1
– COP9 signalosome complex subunit 5; TAIR: AT1G71230.1 COP9-signalosome 5B; Swiss-Prot: sp|Q9FVU9|CSN5A_ARATH COP9 signalosome complex subunit 5a; TrEMBL-Plants: tr|G7JCC9|G7JCC9_MEDTR COP9 signalosome complex subunit 5; Found in the gene: LotjaGi1g1v0393500
Domains
13
LotjaGi1g1v0393500.2
– COP9 signalosome complex subunit 5; TAIR: AT1G71230.1 COP9-signalosome 5B; Swiss-Prot: sp|Q9FVU9|CSN5A_ARATH COP9 signalosome complex subunit 5a; TrEMBL-Plants: tr|G7JCC9|G7JCC9_MEDTR COP9 signalosome complex subunit 5; Found in the gene: LotjaGi1g1v0393500
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd08069 CDD 1 50.00