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IPR041084 is a Nicastrin, small lobe.
<p>This domain is part of the protein Nicastrin, a component of gamma secretase present in Homo sapiens. Gamma-secretase is thought to contribute to Alzheimer's disease development by generating beta-amyloid peptides. This domain is the known as the small lobe which forms the 'lid'. The lid is an extended surface loop that covers the hydrophilic pocket that is thought to be responsible for substrate recruitment. On substrate binding, the large lobe is thought to rotate relative to the small lobe [[cite:PUB00076828]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nicastrin; TAIR: AT3G52640.1 Zn-dependent exopeptidases superfamily protein; Swiss-Prot: sp|Q8GUM5|NICA_ARATH Nicastrin; TrEMBL-Plants: tr|A0A0B2QWJ0|A0A0B2QWJ0_GLYSO Nicastrin; Found in the gene: LotjaGi6g1v0054700 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03881 | CDD | 1 | 100.00 |