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IPR008710 is a Nicastrin.
<p>Nicastrin and presenilin are two major components of the gamma-secretase complex, which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch. Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin) [[cite:PUB00011399]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | ||
| Biological process | Protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nicalin-1-like [Glycine max] gi|356539234|ref|XP_003538104.1| | 13 | ||
| – | PREDICTED: nicastrin-like [Glycine max] gi|356539812|ref|XP_003538387.1| | 12 | ||
| – | Nicastrin; TAIR: AT3G52640.1 Zn-dependent exopeptidases superfamily protein; Swiss-Prot: sp|Q8GUM5|NICA_ARATH Nicastrin; TrEMBL-Plants: tr|A0A0B2QWJ0|A0A0B2QWJ0_GLYSO Nicastrin; Found in the gene: LotjaGi6g1v0054700 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03881 | CDD | 1 | 33.33 |